Mechanisms of Ferroptosis

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2016 Apr 7

PMID 27048822

Citations 664

Authors

Jennifer Yinuo Cao

Scott J Dixon

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a non-apoptotic form of cell death that can be triggered by small molecules or conditions that inhibit glutathione biosynthesis or the glutathione-dependent antioxidant enzyme glutathione peroxidase 4 (GPX4). This lethal process is defined by the iron-dependent accumulation of lipid reactive oxygen species and depletion of plasma membrane polyunsaturated fatty acids. Cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression may be sensitized to this process. Conversely, a number of small molecule inhibitors of ferroptosis have been identified, including ferrostatin-1 and liproxstatin-1, which can block pathological cell death events in brain, kidney and other tissues. Recent work has identified a number of genes required for ferroptosis, including those involved in lipid and amino acid metabolism. Outstanding questions include the relationship between ferroptosis and other forms of cell death, and whether activation or inhibition of ferroptosis can be exploited to achieve desirable therapeutic ends.

Citing Articles

Regulation of Ferroptosis in Cancer and Immune Cells.

Jang N, Kim I, Jung D, Chung Y, Kang Y Immune Netw. 2025; 25(1):e6.

PMID: 40078787 PMC: 11896659. DOI: 10.4110/in.2025.25.e6.

N6-methyadenosine-modified YWHAE mRNA promotes proliferation and inhibits ferroptosis in hepatoblastoma by mediating SLC7A11 expression.

Zhou J, Wang J, Yang L, Fu T, Li H, Shan Y Oncogene. 2025; .

PMID: 40074884 DOI: 10.1038/s41388-025-03334-y.

Neuroprotective effects of ethanol extraction from Diels on chronic cerebral hypoperfusion: modulation of the System Xc-/GSH/GPX4 axis to alleviate oxidative stress and ferroptosis.

Cheng J, Ma X, Tao J, Jiang X, Chen P, Duan X Front Pharmacol. 2025; 16:1552228.

PMID: 40070574 PMC: 11893507. DOI: 10.3389/fphar.2025.1552228.

Major heme proteins hemoglobin and myoglobin with respect to their roles in oxidative stress - a brief review.

Sil R, Chakraborti A Front Chem. 2025; 13:1543455.

PMID: 40070406 PMC: 11893434. DOI: 10.3389/fchem.2025.1543455.

Yersiniabactin produced by promotes intestinal inflammation through lipid peroxidation and ferroptosis.

Wang H, Chen B, Xiao P, Han D, Gao B, Yan Y Front Microbiol. 2025; 16:1542801.

PMID: 40034497 PMC: 11872927. DOI: 10.3389/fmicb.2025.1542801.

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