Cranberry-derived Bioactives for the Prevention and Treatment of Urinary Tract Infections: Antimicrobial Mechanisms and Global Research Trends in Nutraceutical Applications

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2025 Mar 13

PMID 40078413

Authors

Himanshu Jangid

Amrullah Shidiki

Gaurav Kumar

Affiliations

Soon will be listed here.

Abstract

Introduction: Urinary tract infections (UTIs) are a global health concern, increasingly complicated by antibiotic resistance. Cranberry-derived bioactive compounds, particularly proanthocyanidins (PACs), have emerged as a promising non-antibiotic strategy for UTI prevention. This review examines their efficacy, mechanisms of action, and the evolving research landscape through bibliometric analysis.

Methods: A comprehensive literature review was conducted to assess the role of cranberry metabolites in UTI prevention, focusing on anti-adhesive and antimicrobial mechanisms. Additionally, a bibliometric analysis of publications from 1962 to 2024 was performed to evaluate research trends, collaboration networks, and thematic developments.

Results: Cranberry metabolites, particularly A-type PACs, flavonoids, and phenolic acids, inhibit adhesion to urothelial cells, reducing UTI recurrence. Gut microbiota-driven transformation of PACs into bioactive metabolites enhances their efficacy, while cranberry oligosaccharides disrupt biofilm formation in high-risk populations. Bibliometric analysis reveals a surge in research interest post-2000, with increasing global collaborations and a focus on clinical applications.

Discussion And Conclusion: Cranberry bioactives demonstrate significant potential in UTI management, yet variations in formulation, dosage, and metabolic bioavailability present challenges. The growing research interest underscores the need for standardized clinical studies to optimize therapeutic efficacy and establish evidence-based guidelines for their use.

References

Fernandez-Puentes V, Uberos J, Rodriguez-Belmonte R, Nogueras-Ocana M, Blanca-Jover E, Narbona-Lopez E . [Efficacy and safety profile of cranberry in infants and children with recurrent urinary tract infection]. An Pediatr (Barc). 2014; 82(6):397-403. DOI: 10.1016/j.anpedi.2014.08.012. View

Peng M, Fang Y, Hu W, Huang Q . The pharmacological activities of Compound Salvia Plebeia Granules on treating urinary tract infection. J Ethnopharmacol. 2010; 129(1):59-63. DOI: 10.1016/j.jep.2010.02.029. View

Foo L, Lu Y, HOWELL A, Vorsa N . The structure of cranberry proanthocyanidins which inhibit adherence of uropathogenic P-fimbriated Escherichia coli in vitro. Phytochemistry. 2000; 54(2):173-81. DOI: 10.1016/s0031-9422(99)00573-7. View

Baron G, Altomare A, Regazzoni L, Fumagalli L, Artasensi A, Borghi E . Profiling Vaccinium macrocarpon components and metabolites in human urine and the urine ex-vivo effect on Candida albicans adhesion and biofilm-formation. Biochem Pharmacol. 2019; 173:113726. DOI: 10.1016/j.bcp.2019.113726. View

Wagenlehner F, Nicolle L, Bartoletti R, Gales A, Grigoryan L, Huang H . A global perspective on improving patient care in uncomplicated urinary tract infection: expert consensus and practical guidance. J Glob Antimicrob Resist. 2021; 28:18-29. DOI: 10.1016/j.jgar.2021.11.008. View

Duffey K, Sutherland L . Adult consumers of cranberry juice cocktail have lower C-reactive protein levels compared with nonconsumers. Nutr Res. 2014; 35(2):118-26. DOI: 10.1016/j.nutres.2014.11.005. View

Bhargava K, Nath G, Bhargava A, Kumari R, Aseri G, Jain N . Bacterial profile and antibiotic susceptibility pattern of uropathogens causing urinary tract infection in the eastern part of Northern India. Front Microbiol. 2022; 13:965053. PMC: 9396120. DOI: 10.3389/fmicb.2022.965053. View

Dehdari S, Hajimehdipoor H . Medicinal Properties of Linn. in Traditional Medicine and Modern Phytotherapy: A Review Article. Iran J Public Health. 2018; 47(2):188-197. PMC: 5810381. View

Griebling T . Urologic diseases in America project: trends in resource use for urinary tract infections in women. J Urol. 2005; 173(4):1281-7. DOI: 10.1097/01.ju.0000155596.98780.82. View

10.

Jalil M, Al Atbee M . The prevalence of multiple drug resistance Escherichia coli and Klebsiella pneumoniae isolated from patients with urinary tract infections. J Clin Lab Anal. 2022; 36(9):e24619. PMC: 9459318. DOI: 10.1002/jcla.24619. View

11.

Nwobodo D, Ugwu M, Oliseloke Anie C, Al-Ouqaili M, Ikem J, Victor Chigozie U . Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace. J Clin Lab Anal. 2022; 36(9):e24655. PMC: 9459344. DOI: 10.1002/jcla.24655. View

12.

Tegegne K, Wagaw G, Gebeyehu N, Yirdaw L, Shewangashaw N, Kassaw M . Prevalence of urinary tract infections and risk factors among diabetic patients in Ethiopia, a systematic review and meta-analysis. PLoS One. 2023; 18(1):e0278028. PMC: 9844928. DOI: 10.1371/journal.pone.0278028. View

13.

Liya S, Siddique R . Determination of Antimicrobial Activity of Some Commercial Fruit (Apple, Papaya, Lemon and Strawberry) Against Bacteria Causing Urinary Tract Infection. Eur J Microbiol Immunol (Bp). 2018; 8(3):95-99. PMC: 6186015. DOI: 10.1556/1886.2018.00014. View

14.

Pappas E, Schaich K . Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stability. Crit Rev Food Sci Nutr. 2010; 49(9):741-81. DOI: 10.1080/10408390802145377. View

15.

Liu H, Howell A, Zhang D, Khoo C . A randomized, double-blind, placebo-controlled pilot study to assess bacterial anti-adhesive activity in human urine following consumption of a cranberry supplement. Food Funct. 2019; 10(12):7645-7652. DOI: 10.1039/c9fo01198f. View

16.

Duncan S, Conti E, Ricci L, Walker A . Links between Diet, Intestinal Anaerobes, Microbial Metabolites and Health. Biomedicines. 2023; 11(5). PMC: 10216541. DOI: 10.3390/biomedicines11051338. View

17.

Juthani-Mehta M, Van Ness P, Bianco L, Rink A, Rubeck S, Ginter S . Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial. JAMA. 2016; 316(18):1879-1887. PMC: 5300771. DOI: 10.1001/jama.2016.16141. View

18.

Murali V, Kuttan G . Curculigo orchioides Gaertn Effectively Ameliorates the Uro- and Nephrotoxicities Induced by Cyclophosphamide Administration in Experimental Animals. Integr Cancer Ther. 2015; 15(2):205-15. PMC: 5736055. DOI: 10.1177/1534735415607319. View

19.

Hisano M, Bruschini H, Nicodemo A, Srougi M . Cranberries and lower urinary tract infection prevention. Clinics (Sao Paulo). 2012; 67(6):661-8. PMC: 3370320. DOI: 10.6061/clinics/2012(06)18. View

20.

Muzammil M, Adnan M, Sikandar S, Waheed M, Javed N, Ur Rehman M . Study of Culture and Sensitivity Patterns of Urinary Tract Infections in Patients Presenting with Urinary Symptoms in a Tertiary Care Hospital. Cureus. 2020; 12(2):e7013. PMC: 7081730. DOI: 10.7759/cureus.7013. View