The Ins and Outs of Thymic Epithelial Cell Differentiation and Function

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2025 Mar 11

PMID 40067584

Authors

Minoru Matsumoto

Francisco Sobral

Joao S Cardoso

Takeshi Oya

Koichi Tsuneyama

Mitsuru Matsumoto

Nuno L Alves

Affiliations

Soon will be listed here.

Abstract

The thymus is an essential component of the immune system responsible for producing T cells. It is anatomically divided into two main regions: the outer cortex and the inner medulla. This chapter summarizes our current understanding of thymic stromal cell functions, with a particular focus on the interactions between these cells and T cells. This exploration aims to shed light on the pathogenesis of immune disorders, including autoimmunity.

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