The Role of Tumor-derived Exosomal LncRNA in Tumor Metastasis

Overview

Journal Cancer Gene Ther

Specialties Genetics
Oncology
Pharmacology

Date 2025 Feb 26

PMID 40011710

Authors

Zhile Yu

Jiali Fu

Vanya Mantareva

Ivica Blazevic

Yusong Wu

Dianchang Wen

Tungalag Battulga

Yuqing Wang

Jianye Zhang

Affiliations

Soon will be listed here.

Abstract

Tumor metastasis regulated by multiple complicated pathways is closely related to variations in the tumor microenvironment. Exosomes can regulate the tumor microenvironment through various mechanisms. Exosomes derived from tumor cells carry a variety of substances, including long non-coding RNAs (lncRNAs), play important roles in intercellular communication and act as critical determinants influencing tumor metastasis. In this review, we elaborate on several pivotal processes through which lncRNAs regulate tumor metastasis, including the regulation of epithelial‒mesenchymal transition, promotion of angiogenesis and lymphangiogenesis, enhancement of the stemness of tumor cells, and evasion of immune clearance. Additionally, we comprehensively summarized a diverse array of potential tumor-derived exosomal lncRNA biomarkers to facilitate accurate diagnosis and prognosis in a clinical setting.

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