Boosting the X Factor: Increasing XBP1s-mediated ER Stress Signaling Protects Motor Neurons in ALS/FTD
  Overview
        Overview
              Journal
              Mol Ther
            
          
                      
              Publisher
              Cell Press
            
          
                      
              
                Specialties
              
              
                                  Molecular Biology
                  
Pharmacology
                              
            
          
          Pharmacology
            Date
            2025 Feb 25
          
          
            PMID
            39999835
          
          
          
                      
  
  Authors
          Authors
  Affiliations
        Affiliations
    Soon will be listed here.
  
  References
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    . Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease. Cell Death Differ. 2011; 18(6):1071-81.
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    Scheper W, Hoozemans J, Hoogenraad C, Rozemuller A, Eikelenboom P, Baas F
    
    . Rab6 is increased in Alzheimer's disease brain and correlates with endoplasmic reticulum stress. Neuropathol Appl Neurobiol. 2007; 33(5):523-32.
    
          DOI: 10.1111/j.1365-2990.2007.00846.x.
    
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    Yuan S, She D, Jiang S, Deng N, Peng J, Ma L
    
    . Endoplasmic reticulum stress and therapeutic strategies in metabolic, neurodegenerative diseases and cancer. Mol Med. 2024; 30(1):40.
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          DOI: 10.1186/s10020-024-00808-9.
    
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    Krokowski D, Han J, Saikia M, Majumder M, Yuan C, Guan B
    
    . A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. J Biol Chem. 2013; 288(24):17202-13.
          PMC: 3682525.
    
          DOI: 10.1074/jbc.M113.466920.
    
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    Ren J, Bi Y, Sowers J, Hetz C, Zhang Y
    
    . Endoplasmic reticulum stress and unfolded protein response in cardiovascular diseases. Nat Rev Cardiol. 2021; 18(7):499-521.
    
          DOI: 10.1038/s41569-021-00511-w.
    
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