Restoring the Supply Lines: Removing Roadblocks to Fatty Acid Uptake Enhances T Cell-driven Cancer Fight
Overview
Overview
Journal
Signal Transduct Target Ther
Specialties
Cell Biology
Pharmacology
Pharmacology
Date
2025 Feb 13
PMID
39948077
Authors
Affiliations
Affiliations
Soon will be listed here.
References
1.
Ma X, Bi E, Lu Y, Su P, Huang C, Liu L
. Cholesterol Induces CD8 T Cell Exhaustion in the Tumor Microenvironment. Cell Metab. 2019; 30(1):143-156.e5.
PMC: 7061417.
DOI: 10.1016/j.cmet.2019.04.002.
View
2.
Baldwin J, Heuser-Loy C, Saha T, Schelker R, Slavkovic-Lukic D, Strieder N
. Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Cell. 2024; 187(23):6614-6630.e21.
PMC: 11623344.
DOI: 10.1016/j.cell.2024.08.029.
View
3.
Na B, Kim H, Piragyte I, Oh H, Kwon M, Akber U
. TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse. J Cell Biol. 2015; 209(1):143-62.
PMC: 4395477.
DOI: 10.1083/jcb.201407130.
View
4.
Hwang S, Awasthi D, Jeong J, Sandoval T, Chae C, Ramos Y
. Transgelin 2 guards T cell lipid metabolism and antitumour function. Nature. 2024; 635(8040):1010-1018.
DOI: 10.1038/s41586-024-08071-y.
View
5.
Hurst K, Lawrence K, Essman M, Walton Z, Leddy L, Thaxton J
. Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8 T Cells. Cancer Immunol Res. 2019; 7(3):476-486.
PMC: 6397687.
DOI: 10.1158/2326-6066.CIR-18-0182.
View