A Joint Analysis of RNA-DNA and DNA-DNA Interactomes Reveals Their Strong Association

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2025 Feb 13

PMID 39940904

Authors

Dmitry S Zvezdin

Artyom A Tyukaev

Anastasia A Zharikova

Andrey A Mironov

Affiliations

Soon will be listed here.

Abstract

At the moment, many non-coding RNAs that perform a variety of functions in the regulation of chromatin processes are known. An increasing number of protocols allow researchers to study RNA-DNA interactions and shed light on new aspects of the RNA-chromatin interactome. The Hi-C protocol, which enables the study of chromatin's three-dimensional organization, has already led to numerous discoveries in the field of genome 3D organization. We conducted a comprehensive joint analysis of the RNA-DNA interactome and chromatin structure across different human and mouse cell lines. We show that these two phenomena are closely related in many respects, with the nature of this relationship being both tissue specific and conserved across humans and mice.

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