Spatial Transcriptomics in Human Cardiac Tissue

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2025 Feb 13

PMID 39940764

Authors

Quynh Nguyen

Lin Wei Tung

Bruce Lin

Raam Sivakumar

Funda Sar

Gurpreet Singhera

Ying Wang

Jeremy Parker

Stephane Le Bihan

Amrit Singh

Fabio M V Rossi

Colin Collins

Jamil Bashir

Zachary Laksman

Affiliations

Soon will be listed here.

Abstract

Spatial transcriptomics has transformed our understanding of gene expression by preserving the spatial context within tissues. This review focuses on the application of spatial transcriptomics in human cardiac tissues, exploring current technologies with a focus on commercially available platforms. We also highlight key studies utilizing spatial transcriptomics to investigate cardiac development, electro-anatomy, immunology, and ischemic heart disease. These studies demonstrate how spatial transcriptomics can be used in conjunction with other omics technologies to provide a more comprehensive picture of human health and disease. Despite its transformative potential, spatial transcriptomics comes with several challenges that limit its widespread adoption and broader application. By addressing these limitations and fostering interdisciplinary collaboration, spatial transcriptomics has the potential to become an essential tool in cardiovascular research. We hope this review serves as a practical guide for researchers interested in adopting spatial transcriptomics, particularly those with limited prior experience, by providing insights into current technologies, applications, and considerations for successful implementation.

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