Colin Collins
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Explore the profile of Colin Collins including associated specialties, affiliations and a list of published articles.
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76
Citations
3007
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Recent Articles
1.
Zhang S, Xue H, Wong N, Doerksen T, Ban F, Anderson S, et al.
Mol Cancer Ther
. 2025 Mar;
PMID: 40062378
Nucleobase analogue (NBA) drugs, such as 5-fluorouracil (5-FU), are effective chemotherapeutics, but their clinical use is limited by severe side effects. Compelling evidence suggests that the use of S-methyl-5'-thioadenosine (MTA)...
2.
Nguyen Q, Tung L, Lin B, Sivakumar R, Sar F, Singhera G, et al.
Int J Mol Sci
. 2025 Feb;
26(3).
PMID: 39940764
Spatial transcriptomics has transformed our understanding of gene expression by preserving the spatial context within tissues. This review focuses on the application of spatial transcriptomics in human cardiac tissues, exploring...
3.
Huang K, Ashraf M, Rohani L, Luo Y, Sacayanan A, Huang H, et al.
Circ Genom Precis Med
. 2025 Jan;
18(1):e004412.
PMID: 39851047
Background: Protein-truncating mutations in the titin gene are associated with increased risk of atrial fibrillation. However, little is known about the underlying pathophysiology. Methods: We identified a heterozygous titin truncating...
4.
Kang N, Xue H, Wong N, Lin Y, Classen A, Wu R, et al.
Mol Cancer Res
. 2025 Jan;
PMID: 39776163
Prostate cancer (PCa) is mainly managed with androgen deprivation therapy (ADT), but this often leads to a dormant state and subsequent relapse as lethal castration-resistant prostate cancer (CRPC). Using our...
5.
Mao Y, Lin Y, Wong N, Volik S, Sar F, Collins C, et al.
Bioinformatics
. 2024 Feb;
40(2).
PMID: 38390963
Motivation: A patient's disease phenotype can be driven and determined by specific groups of cells whose marker genes are either unknown or can only be detected at late-stage using conventional...
6.
Xia C, Saranchova I, Finkel P, Besoiu S, Munro L, Pfeifer C, et al.
Commun Biol
. 2024 Jan;
7(1):12.
PMID: 38172434
Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less...
7.
Van Espen B, Oo H, Collins C, Fazli L, Molinolo A, Yip K, et al.
Mol Cancer Res
. 2023 Oct;
22(1):41-54.
PMID: 37831068
Implications: RNF185 is identified as an important regulator of prostate cancer migration and metastasis, in part due to its regulation of COL3A1. Both RNF185 and COL3A1 may serve as novel...
8.
Kang N, Xue H, Lin Y, Dong X, Classen A, Wu R, et al.
Cancer Gene Ther
. 2023 Jul;
30(10):1382-1389.
PMID: 37452083
Androgen deprivation therapy (ADT) is the standard care for advanced prostate cancer (PCa) patients. Unfortunately, although tumors respond well initially, they enter dormancy and eventually progress to fatal/incurable castration-resistant prostate...
9.
Van Espen B, Oo H, Collins C, Fazli L, Molinolo A, Murad R, et al.
bioRxiv
. 2023 Jul;
PMID: 37425866
RNF185 is a RING finger domain-containing ubiquitin ligase implicated in ER-associated degradation. Prostate tumor patient data analysis revealed a negative correlation between RNF185 expression and prostate cancer progression and metastasis....
10.
Ramos L, Truong S, Zhai B, Joshi J, Ghaidi F, Lizardo M, et al.
Clin Cancer Res
. 2023 Jun;
29(17):3541-3553.
PMID: 37279093
Purpose: Histone deacetylase (HDAC) inhibition has been shown to induce pharmacologic "BRCAness" in cancer cells with proficient DNA repair activity. This provides a rationale for exploring combination treatments with HDAC...