Influence of Reactive Oxygen Species on Wound Healing and Tissue Regeneration in Periodontal and Peri-Implant Tissues in Diabetic Patients

Overview

Journal Antioxidants (Basel)

Date 2023 Sep 28

PMID 37760090

Authors

Prima Buranasin

Hiromi Kominato

Koji Mizutani

Risako Mikami

Natsumi Saito

Kohei Takeda

Takanori Iwata

Affiliations

Soon will be listed here.

Abstract

Diabetes mellitus (DM) is associated with periodontal disease. Clinically, periodontal treatment is less effective for patients with DM. Oxidative stress is one of the mechanisms that link DM to periodontitis. The production of reactive oxygen species (ROS) is increased in the periodontal tissues of patients with DM and is involved in the development of insulin resistance in periodontal tissues. Insulin resistance decreases Akt activation and inhibits cell proliferation and angiogenesis. This results in the deterioration of wound healing and tissue repair in periodontal tissues. Antioxidants and insulin resistance ameliorants may inhibit ROS production and improve wound healing, which is worsened by DM. This manuscript provides a comprehensive review of the most recent basic and clinical evidence regarding the generation of ROS in periodontal tissues resulting from microbial challenge and DM. This study also delves into the impact of oxidative stress on wound healing in the context of periodontal and dental implant therapies. Furthermore, it discusses the potential benefits of administering antioxidants and anti-insulin resistance medications, which have been shown to counteract ROS production and inflammation. This approach may potentially enhance wound healing, especially in cases exacerbated by hyperglycemic conditions.

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References

Golz L, Memmert S, Rath-Deschner B, Jager A, Appel T, Baumgarten G . LPS from P. gingivalis and hypoxia increases oxidative stress in periodontal ligament fibroblasts and contributes to periodontitis. Mediators Inflamm. 2014; 2014:986264. PMC: 4211166. DOI: 10.1155/2014/986264. View

Hou M, Lee R, Du Z, Hamlet S, Vaquette C, Ivanovski S . The influence of high-dose systemic zoledronate administration on osseointegration of implants with different surface topography. J Periodontal Res. 2019; 54(6):633-643. DOI: 10.1111/jre.12664. View

Ueno T, Yamada M, Igarashi Y, Ogawa T . N-acetyl cysteine protects osteoblastic function from oxidative stress. J Biomed Mater Res A. 2011; 99(4):523-31. DOI: 10.1002/jbm.a.33211. View

Konopka T, Krol K, Kopec W, Gerber H . Total antioxidant status and 8-hydroxy-2'-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients. Arch Immunol Ther Exp (Warsz). 2007; 55(6):417-22. PMC: 2766448. DOI: 10.1007/s00005-007-0047-1. View

Baumgartner-Parzer S, Wagner L, Pettermann M, Grillari J, Gessl A, Waldhausl W . High-glucose--triggered apoptosis in cultured endothelial cells. Diabetes. 1995; 44(11):1323-7. DOI: 10.2337/diab.44.11.1323. View

Miron R, Sculean A, Cochran D, Froum S, Zucchelli G, Nemcovsky C . Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol. 2016; 43(8):668-83. DOI: 10.1111/jcpe.12546. View

Li X, Tang L, Lin Y, Xie G . Role of vitamin C in wound healing after dental implant surgery in patients treated with bone grafts and patients with chronic periodontitis. Clin Implant Dent Relat Res. 2018; 20(5):793-798. DOI: 10.1111/cid.12647. View

Baltacioglu E, Sukuroglu E . Protein carbonyl levels in serum, saliva and gingival crevicular fluid in patients with chronic and aggressive periodontitis. Saudi Dent J. 2019; 31(1):23-30. PMC: 6349948. DOI: 10.1016/j.sdentj.2018.09.003. View

Landzberg M, Doering H, Aboodi G, Tenenbaum H, Glogauer M . Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease. J Periodontal Res. 2014; 50(3):330-6. DOI: 10.1111/jre.12211. View

10.

Raut C, Sethi K . Comparative evaluation of co-enzyme Q10 and Melaleuca alternifolia as antioxidant gels in treatment of chronic periodontitis: A clinical study. Contemp Clin Dent. 2016; 7(3):377-81. PMC: 5004553. DOI: 10.4103/0976-237X.188572. View

11.

Ray P, Huang B, Tsuji Y . Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012; 24(5):981-90. PMC: 3454471. DOI: 10.1016/j.cellsig.2012.01.008. View

12.

Borgnakke W, Ylostalo P, Taylor G, Genco R . Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. J Clin Periodontol. 2013; 40 Suppl 14:S135-52. DOI: 10.1111/jcpe.12080. View

13.

Mailoa J, Lin G, Khoshkam V, MacEachern M, Chan H, Wang H . Long-Term Effect of Four Surgical Periodontal Therapies and One Non-Surgical Therapy: A Systematic Review and Meta-Analysis. J Periodontol. 2015; 86(10):1150-8. DOI: 10.1902/jop.2015.150159. View

14.

Mizutani K, Shioyama H, Matsuura T, Mikami R, Takeda K, Izumi Y . Periodontal regenerative therapy in patients with type 2 diabetes using minimally invasive surgical technique with enamel matrix derivative under 3-year observation: A prospective cohort study. J Periodontol. 2020; 92(9):1262-1273. DOI: 10.1002/JPER.20-0590. View

15.

Gestrelius S, Andersson C, Lidstrom D, Hammarstrom L, Somerman M . In vitro studies on periodontal ligament cells and enamel matrix derivative. J Clin Periodontol. 1997; 24(9 Pt 2):685-92. DOI: 10.1111/j.1600-051x.1997.tb00250.x. View

16.

Su H, Gornitsky M, Velly A, Yu H, Benarroch M, Schipper H . Salivary DNA, lipid, and protein oxidation in nonsmokers with periodontal disease. Free Radic Biol Med. 2009; 46(7):914-21. DOI: 10.1016/j.freeradbiomed.2009.01.008. View

17.

Kunsongkeit P, Okuma N, Rassameemasmaung S, Chaivanit P . Effect of Vitamin C as an Adjunct in Nonsurgical Periodontal Therapy in Uncontrolled Type 2 Diabetes Mellitus Patients. Eur J Dent. 2019; 13(3):444-449. PMC: 6890498. DOI: 10.1055/s-0039-1693207. View

18.

Mathur A, Mathur L, Manohar B, Mathur H, Shankarapillai R, Shetty N . Antioxidant therapy as monotherapy or as an adjunct to treatment of periodontal diseases. J Indian Soc Periodontol. 2013; 17(1):21-4. PMC: 3636937. DOI: 10.4103/0972-124X.107469. View

19.

Du Z, Lee R, Hamlet S, Doan N, Ivanovski S, Xiao Y . Evaluation of the first maxillary molar post-extraction socket as a model for dental implant osseointegration research. Clin Oral Implants Res. 2015; 27(12):1469-1478. DOI: 10.1111/clr.12571. View

20.

Sies H . Oxidative stress: oxidants and antioxidants. Exp Physiol. 1997; 82(2):291-5. DOI: 10.1113/expphysiol.1997.sp004024. View