Knowledge, Attitude and Practice Among Dental Professionals Related to Periodontitis and Alzheimer's Disease

Overview

Journal J Pharm Bioallied Sci

Date 2025 Feb 10

PMID 39926734

Authors

Ruchi Pandey

Radhika Pujara

Priyanka Bansal

Roshni Lekhi

Pooja Palwankar

Lipika Gopal

Affiliations

Soon will be listed here.

Abstract

Background: Periodontitis is chronic infection and is linked to systemic diseases like Alzheimer's disease (AD). AD is a neurodegenerative disorder occurring due to accumulation of aggregates of amyloid β peptide and tau proteins. The current study aims to assess the knowledge, attitude, and practice about treating AD cases.

Material And Method: Questionnaire-based survey was done on 270 dental professionals and dental students. Data was analyzed using bar chart, and hypothesis was tested using Chi-Square test.

Results: There is an association between practical knowledge and attitude among dental professionals and students, but there is lack of practice-based approach for treating Alzheimer's patients.

Conclusion: The dental professionals have knowledge regarding perio-systemic link, but still need to upgrade their understanding toward AD with periodontitis.

References

Holmes C . Review: systemic inflammation and Alzheimer's disease. Neuropathol Appl Neurobiol. 2012; 39(1):51-68. DOI: 10.1111/j.1365-2990.2012.01307.x. View

Sharma A . Virulence mechanisms of Tannerella forsythia. Periodontol 2000. 2010; 54(1):106-16. PMC: 2934765. DOI: 10.1111/j.1600-0757.2009.00332.x. View

Perry V, Cunningham C, Holmes C . Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol. 2007; 7(2):161-7. DOI: 10.1038/nri2015. View

Al-Habashneh R, Barghout N, Humbert L, Khader Y, Alwaeli H . Diabetes and oral health: doctors' knowledge, perception and practices. J Eval Clin Pract. 2010; 16(5):976-80. DOI: 10.1111/j.1365-2753.2009.01245.x. View

Yilmaz O . The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay. Microbiology (Reading). 2008; 154(Pt 10):2897-2903. PMC: 2639765. DOI: 10.1099/mic.0.2008/021220-0. View

Sun J, Tong D, Sun C, Wang X, Zuo Z, Liu Y . Knowledge, attitude, and practice toward self-control of dental plaque among patients with periodontal diseases: a cross-sectional study. BMC Oral Health. 2023; 23(1):628. PMC: 10475179. DOI: 10.1186/s12903-023-03352-w. View

Chen C, Wu Y, Chang Y . Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study. Alzheimers Res Ther. 2017; 9(1):56. PMC: 5547465. DOI: 10.1186/s13195-017-0282-6. View

Heppner F, Ransohoff R, Becher B . Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci. 2015; 16(6):358-72. DOI: 10.1038/nrn3880. View

Holt S, Kesavalu L, Walker S, Genco C . Virulence factors of Porphyromonas gingivalis. Periodontol 2000. 1999; 20:168-238. DOI: 10.1111/j.1600-0757.1999.tb00162.x. View

10.

Schaper S, Meyer-Rotz S, Bartels C, Wiltfang J, Rodig T, Schott B . Dental Care of Patients With Dementia: A Survey on Practice Equipment, Training, and Dental Treatment. Front Oral Health. 2022; 2:682139. PMC: 8757740. DOI: 10.3389/froh.2021.682139. View

11.

Janakiram C, Mehta A, Venkitachalam R . Prevalence of periodontal disease among adults in India: A systematic review and meta-analysis. J Oral Biol Craniofac Res. 2020; 10(4):800-806. PMC: 7649635. DOI: 10.1016/j.jobcr.2020.10.016. View

12.

Lee J, Meijer E, Langa K, Ganguli M, Varghese M, Banerjee J . Prevalence of dementia in India: National and state estimates from a nationwide study. Alzheimers Dement. 2023; 19(7):2898-2912. PMC: 10338640. DOI: 10.1002/alz.12928. View