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Systemic Infections and Inflammation Affect Chronic Neurodegeneration

Overview
Journal Nat Rev Immunol
Date 2007 Jan 16
PMID 17220915
Citations 468
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Abstract

It is well known that systemic infections cause flare-ups of disease in individuals with asthma and rheumatoid arthritis, and that relapses in multiple sclerosis can often be associated with upper respiratory-tract infections. Here we review evidence to support our hypothesis that in chronic neurodegenerative diseases such as Alzheimer's disease, with an ongoing innate immune response in the brain, systemic infections and inflammation can cause acute exacerbations of symptoms and drive the progression of neurodegeneration.

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