Clinical Significance of Neutrophil Extracellular Traps Biomarkers in Thrombosis

Overview

Journal Thromb J

Publisher Biomed Central

Date 2022 Oct 12

PMID 36224604

Authors

Xiangbo Xu

Yuting Wu

Shixue Xu

Yue Yin

Walter Ageno

Valerio De Stefano

Qingchun Zhao

Xingshun Qi

Affiliations

Soon will be listed here.

Abstract

Neutrophil extracellular traps (NETs) may be associated with the development of thrombosis. Experimental studies have confirmed the presence of NETs in thrombi specimens and potential role of NETs in the mechanisms of thrombosis. Clinical studies also have demonstrated significant changes in the levels of serum or plasma NETs biomarkers, such as citrullinated histones, myeloperoxidase, neutrophil elastase, nucleosomes, DNA, and their complexes in patients with thrombosis. This paper aims to comprehensively review the currently available evidence regarding the change in the levels of NETs biomarkers in patients with thrombosis, summarize the role of NETs and its biomarkers in the development and prognostic assessment of venous thromboembolism, coronary artery diseases, ischemic stroke, cancer-associated thromboembolism, and coronavirus disease 2019-associated thromboembolism, explore the potential therapeutic implications of NETs, and further discuss the shortcomings of existing NETs biomarkers in serum and plasma and their detection methods.

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