Comparing Simulations of Actin Filament Compression Reveals Tradeoff Between Computational Cost and Capturing Supertwist

Overview

Journal MicroPubl Biol

Date 2025 Feb 6

PMID 39911911

Authors

Blair Lyons

Saurabh S Mogre

Karthik Vegesna

Jessica S Yu

Mark Hansen

Aadarsh Raghunathan

Graham T Johnson

Eran Agmon

Matthew Akamatsu

Affiliations

Soon will be listed here.

Abstract

The dynamic bending and twisting of actin drives numerous cellular processes. To compare how different spatial scales in actin models capture these dynamics, we developed two models of actin filaments: one at monomer-scale using ReaDDy and one at fiber-scale using Cytosim. Simulating filament compression across a range of velocities, we found a divergence between the monomer- and fiber-scale simulations; notably, the monomer-scale simulations more effectively captured filament supertwist, characteristic of helical structure, but at a higher computational cost. Such comparisons can aid in designing more efficient and accurate multi-scale biological models. Interactive visualizations at https://simularium.github.io/subcell-website.

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