The Role of Long Non-coding RNAs in Cardiovascular Diseases: A Comprehensive Review

Overview

Journal Noncoding RNA Res

Date 2025 Feb 3

PMID 39896344

Authors

Xuena Xie

Meiwen Huang

Shudong Ma

Qiqi Xin

Yuying Wang

Lantian Hu

Han Zhao

Pengqi Li

Mei Liu

Rong Yuan

Yu Miao

Yizhun Zhu

Weihong Cong

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, posing significant challenges to healthcare systems. Despite advances in medical interventions, the molecular mechanisms underlying CVDs are not yet fully understood. For decades, protein-coding genes have been the focus of CVD research. However, recent advances in genomics have highlighted the importance of long non-coding RNAs (lncRNAs) in cardiovascular health and disease. Changes in lncRNA expression specific to tissues may result from various internal or external factors, leading to tissue damage, organ dysfunction, and disease. In this review, we provide a comprehensive discussion of the regulatory mechanisms underlying lncRNAs and their roles in the pathogenesis and progression of CVDs, such as coronary heart disease, atherosclerosis, heart failure, arrhythmias, cardiomyopathies, and diabetic cardiomyopathy, to explore their potential as therapeutic targets and diagnostic biomarkers.

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