Long Noncoding RNA Regulates the Proliferation, Migration, and Apoptosis of Human Venous Endothelial Cells Via SMYD3

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2020 Jun 30

PMID 32596350

Citations 4

Authors

Ganhua You

Xiangshu Long

Fang Song

Jing Huang

Maobo Tian

Yan Xiao

Shiyan Deng

Qiang Wu

Affiliations

Soon will be listed here.

Abstract

Numerous studies have shown that long noncoding RNAs (lncRNAs) play essential roles in the development and progression of human cardiovascular diseases. However, whether lncRNA ezrin antisense RNA 1 () is associated with the progression of coronary heart disease (CHD) remains unclear. Accordingly, the aim of the present study was to evaluate the role of lncRNA in patients with CHD and in human venous endothelial cells (HUVECs). The findings revealed that lncRNA was highly expressed in the peripheral blood of patients with CHD. experiments showed that the overexpression of could enhance proliferation, migration, and apoptosis by upregulating the expression of EZR in HUVECs; downregulation of lncRNA resulted in the opposite effect. lncRNA was also found to regulate SET and MYND domain-containing protein 3 (SMYD3), a histone H3 lysine 4-specific methyltransferase, which subsequently mediated EZR transcription. Collectively, these results demonstrate that lncRNA plays an important role in HUVECs function via SMYD3 signaling.

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