Research Hotspots and Trends of Acupoint and Pain Based on PubMed: a Bibliometric Analysis

Overview

Journal Front Neurol

Date 2025 Feb 3

PMID 39895908

Authors

Zhulin Wu

Wanjun Tan

Siyi Li

Weiqing Zhang

Mingbo Lai

Weijun Luo

Affiliations

Soon will be listed here.

Abstract

Objective: Acupoint-related interventions are the widely utilized modalities in traditional Chinese medicine for the alleviation of pain. This study aims to identify research hotspots and trends by conducting a bibliometric analysis of the relevant literature on acupoint and pain, thereby elucidating future research directions in this field.

Method: A comprehensive search was conducted on PubMed for literature pertaining to acupoint and pain from January 2010 to August 2024. Subsequent bibliometric analyses, encompassing statistical evaluation of bibliographic data, keyword cluster analysis, and co-occurrence analysis, were conducted utilizing the Medpulse database and the Bibliometrix R-package.

Results: A total of 742 articles from 179 journals were included in the analysis, with the majority focusing on complementary and alternative medicine or comprehensive research. The number of publications in this field has shown a consistent annual increase, involving contributions from 19 different countries of corresponding authors. China had the greatest contribution with 407 articles followed by Korea with 25 articles. The leading institutions in terms of publication volume are Chengdu University of Traditional Chinese Medicine, China Medical University, and Kyung Hee University. The topics covered in these articles include acupuncture, transcutaneous electrical acupoint stimulation (TEAS), randomized controlled trials, analgesia, zusanli (st36), systematic review, and anxiety, among others. The main cluster themes are intervention methods for various acupoints and the assessment of their efficacy.

Conclusion: The bibliometric analysis has identified the intervention methods of acupoints and the evaluation of their efficacy in pain management as emerging research focal points. Additionally, anxiety is anticipated to emerge as a future research direction within this domain.

References

Palese A, Cadorin L, Testa M, Geri T, Colloca L, Rossettini G . Contextual factors triggering placebo and nocebo effects in nursing practice: Findings from a national cross-sectional study. J Clin Nurs. 2019; 28(9-10):1966-1978. DOI: 10.1111/jocn.14809. View

Rossettini G, Testa M . Manual therapy RCTs: should we control placebo in placebo control?. Eur J Phys Rehabil Med. 2017; 54(3):500-501. DOI: 10.23736/S1973-9087.17.05024-9. View

Torres-Rosas R, Yehia G, Pena G, Mishra P, Thompson-Bonilla M, Moreno-Eutimio M . Dopamine mediates vagal modulation of the immune system by electroacupuncture. Nat Med. 2014; 20(3):291-5. PMC: 3949155. DOI: 10.1038/nm.3479. View

Melile Mengesha B, Lencha F, Digesa L . Pain assessment practice and associated factors among nurses working at adult care units in public hospitals in Wolaita Zone, Southern Ethiopia, 2021. BMC Nurs. 2022; 21(1):115. PMC: 9102635. DOI: 10.1186/s12912-022-00892-4. View

Dusek J, Kallenberg G, Hughes R, Storrow A, Coyne C, Vago D . Acupuncture in the emergency department for pain management: A BraveNet multi-center feasibility study. Medicine (Baltimore). 2022; 101(9):e28961. PMC: 8896475. DOI: 10.1097/MD.0000000000028961. View

Hohenschurz-Schmidt D, Thomson O, Rossettini G, Miciak M, Newell D, Roberts L . Avoiding nocebo and other undesirable effects in chiropractic, osteopathy and physiotherapy: An invitation to reflect. Musculoskelet Sci Pract. 2022; 62:102677. DOI: 10.1016/j.msksp.2022.102677. View

Moudgil K, Berman B . Traditional Chinese medicine: potential for clinical treatment of rheumatoid arthritis. Expert Rev Clin Immunol. 2014; 10(7):819-22. PMC: 8060809. DOI: 10.1586/1744666X.2014.917963. View

Madmoli Y, Rokhafroz D, Zarea K, Maraghi E . Effects of SP6 and ST36 Acupressure on Pain and Physiological Indexes in Addicted Men: A Single-Blind Randomized Clinical Trial. Addict Health. 2022; 14(1):52-61. PMC: 9057643. DOI: 10.22122/ahj.v14i1.1251. View

Li Z, Shang W, Wang C, Yang K, Guo J . Characteristics and trends in acceptance and commitment therapy research: A bibliometric analysis. Front Psychol. 2022; 13:980848. PMC: 9702511. DOI: 10.3389/fpsyg.2022.980848. View

10.

Bai F, Ma Y, Guo H, Li Y, Xu F, Zhang M . Spinal Cord Glycine Transporter 2 Mediates Bilateral ST35 Acupoints Sensitization in Rats with Knee Osteoarthritis. Evid Based Complement Alternat Med. 2019; 2019:7493286. PMC: 6383421. DOI: 10.1155/2019/7493286. View

11.

Ma Y, Dong M, Zhou K, Mita C, Liu J, Wayne P . Publication Trends in Acupuncture Research: A 20-Year Bibliometric Analysis Based on PubMed. PLoS One. 2016; 11(12):e0168123. PMC: 5156436. DOI: 10.1371/journal.pone.0168123. View

12.

Li Q, Yang W, Liu H, Jiao L, Gong Y, Shi J . Research on Electroacupuncture Parameters for Cancer Pain Based on Data Mining. Integr Cancer Ther. 2023; 22:15347354231192017. PMC: 10411286. DOI: 10.1177/15347354231192017. View

13.

Tan S, Jiang H, Ma Q, Ye X, Fu X, Ren Y . Effects of transcutaneous electrical acupoint stimulation on early postoperative pain and recovery: a comprehensive systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2024; 11:1302057. PMC: 11092893. DOI: 10.3389/fmed.2024.1302057. View

14.

Zhang Y, Peng D, Zhang Q, Huang B, Yang Q, Tang D . µ-TRTX-Ca1a: a novel neurotoxin from Cyriopagopus albostriatus with analgesic effects. Acta Pharmacol Sin. 2018; 40(7):859-866. PMC: 6786292. DOI: 10.1038/s41401-018-0181-9. View

15.

Cheng H, Zhao X, Zhang L, Ma M, Ma X . Surface-Coated Acupuncture Needles as Solid-Phase Microextraction Probes for In Vivo Analysis of Bioactive Molecules in Living Plants by Mass Spectrometry. Metabolites. 2023; 13(2). PMC: 9968076. DOI: 10.3390/metabo13020220. View

16.

Wu Z, Shen Z, Xu Y, Chen S, Xiao S, Ye J . A neural circuit associated with anxiety-like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture. CNS Neurosci Ther. 2023; 30(4):e14520. PMC: 11017463. DOI: 10.1111/cns.14520. View

17.

Zhang W, Zhang L, Yang S, Wen B, Chen J, Chang J . Electroacupuncture ameliorates knee osteoarthritis in rats via inhibiting NLRP3 inflammasome and reducing pyroptosis. Mol Pain. 2022; 19:17448069221147792. PMC: 9841849. DOI: 10.1177/17448069221147792. View

18.

Wu M, Chen K, Chen I, Huang S, Tzeng P, Yeh M . The Efficacy of Acupuncture in Post-Operative Pain Management: A Systematic Review and Meta-Analysis. PLoS One. 2016; 11(3):e0150367. PMC: 4784927. DOI: 10.1371/journal.pone.0150367. View

19.

Kim J, Kim H, Lee J, Jun J, Choi T, Lee M . Acupuncture for the treatment of trigeminal neuralgia: A protocol for the systematic review of randomized controlled trials. Medicine (Baltimore). 2018; 97(11):e0108. PMC: 5882395. DOI: 10.1097/MD.0000000000010108. View

20.

Wang C, Jing H, Sun Z, Yao J, Zhang X, Liu T . A Bibliometric Analysis of Primary Aldosteronism Research From 2000 to 2020. Front Endocrinol (Lausanne). 2021; 12:665912. PMC: 8111213. DOI: 10.3389/fendo.2021.665912. View