Future Perspectives: Advances in Bone/cartilage Organoid Technology and Clinical Potential

Overview

Journal Biomater Transl

Date 2025 Jan 28

PMID 39872930

Authors

Jingtao Huang

Aikang Li

Rongji Liang

Xiaohao Wu

Shicheng Jia

Jiayou Chen

Zilu Jiao

Canfeng Li

Xintao Zhang

Jianjing Lin

Affiliations

Soon will be listed here.

Abstract

Bone and cartilage tissues are essential for movement and structure, yet diseases like osteoarthritis affect millions. Traditional therapies have limitations, necessitating innovative approaches. Organoid technology, leveraging stem cells' regenerative potential, offers a novel platform for disease modelling and therapy. This review focuses on advancements in bone/cartilage organoid technology, highlighting the role of stem cells, biomaterials, and external factors in organoid development. We discuss the implications of these organoids for regenerative medicine, disease research, and personalised treatment strategies, presenting organoids as a promising avenue for enhancing cartilage repair and bone regeneration. Bone/cartilage organoids will play a greater role in the treatment of bone/cartilage diseases in the future, and promote the progress of biological tissue engineering.

Citing Articles

Organoids: the future of disease modelling and therapeutics.

Zhou D, Xia Z, Su J Biomater Transl. 2025; 5(4):335-336.

PMID: 39872927 PMC: 11764190. DOI: 10.12336/biomatertransl.2024.04.001.

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