No Acute Behavioural Effects of Exposure to Styrene: a Safe Level of Exposure?

Overview

Journal Br J Ind Med

Specialty Occupational Medicine

Date 1985 May 1

PMID 3986140

Citations 8

Authors

C Edling

K Ekberg

Affiliations

Soon will be listed here.

Abstract

To determine whether exposure to low levels of styrene (below 110 mg/m3) causes acute behavioural effects and symptoms that may be related to concentrations of styrene in air or urinary mandelic acid or both, 12 men occupationally exposed to styrene were studied and compared with a reference group of 10 unexposed men. Simple reaction time was measured before and after work and information about symptoms was obtained by questionnaire. Active and passive sampling of airborne styrene was carried out and urinary mandelic acid concentrations were measured. Although the size of the study groups is small, the results indicate that exposure to styrene below 110 mg/m3 does not cause any acute adverse effects on the central nervous system.

Citing Articles

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Study of the neurobehavioural toxicity of styrene at low levels of exposure.

Jegaden D, Amann D, Simon J, Habault M, Legoux B, Galopin P Int Arch Occup Environ Health. 1993; 64(7):527-31.

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Increase in neuropsychiatric symptoms after occupational exposure to low levels of styrene.

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Platelet monoamine oxidase B activity in workers exposed to styrene.

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Neuropsychiatric effects of low exposure to styrene.

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References

Gamberale F, Hultengren M . Exposure to styrene. II. Psychological functions. Work Environ Health. 1974; 11(2):86-93. View

LEIBMAN K . Metabolism and toxicity of styrene. Environ Health Perspect. 1975; 11:115-9. PMC: 1475194. DOI: 10.1289/ehp.7511115. View

SOLLENBERG J, BALDESTEN A . Isotachophoretic analysis of mandelic acid, phenylglyoxylic acid, hippuric acid and methylhippuric acid in urine after occupational exposure to styrene, toluene and/or xylene. J Chromatogr. 1977; 132(3):469-76. DOI: 10.1016/s0021-9673(00)82910-6. View

Harkonen H . Relationship of symptoms to occupational styrene exposure and to the findings of electroencephalographic and psychological examinations. Int Arch Occup Environ Health. 1977; 40(4):231-9. DOI: 10.1007/BF00381410. View

Bailey A . A personal diffusion sampler for evaluating time weighted exposure to organic gases and vapours. Ann Occup Hyg. 1977; 20(4):345-56. DOI: 10.1093/annhyg/20.4.345. View

Harkonen H, Lindstrom K, Seppalainen A, Asp S, HERNBERG S . Exposure-response relationship between styrene exposure and central nervous functions. Scand J Work Environ Health. 1978; 4(1):53-9. DOI: 10.5271/sjweh.2723. View

Engstrom J, ASTRAND I, Wigaeus E . Exposure to styrene in a polymerization plant. Uptake in the organism and concentration in subcutaneous adipose tissue. Scand J Work Environ Health. 1978; 4(4):324-9. DOI: 10.5271/sjweh.2693. View

Cherry N, Waldron H, Wells G, WILKINSON R, Wilson H, Jones S . An investigation of the acute behavioural effects of styrene on factory workers. Br J Ind Med. 1980; 37(3):234-40. PMC: 1008701. DOI: 10.1136/oem.37.3.234. View

Cherry N, Rodgers B, Venables H, Waldron H, Wells G . Acute behavioral effects of styrene exposure: a further analysis. Br J Ind Med. 1981; 38(4):346-50. PMC: 1069287. DOI: 10.1136/oem.38.4.346. View

10.

Wilson H, Robertson S, Waldron H, GOMPERTZ D . Effect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour. Br J Ind Med. 1983; 40(1):75-80. PMC: 1009122. DOI: 10.1136/oem.40.1.75. View

11.

Venables H, Cherry N, Waldron H, Buck L, Edling C, Wilson H . Effects of trace levels of nitrous oxide on psychomotor performance. Scand J Work Environ Health. 1983; 9(5):391-6. DOI: 10.5271/sjweh.2395. View

12.

Mutti A, Mazzucchi A, Rustichelli P, Frigeri G, Arfini G, Franchini I . Exposure-effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions. Am J Ind Med. 1984; 5(4):275-86. DOI: 10.1002/ajim.4700050404. View

13.

Flodin U, Edling C, Axelson O . Clinical studies of psychoorganic syndromes among workers with exposure to solvents. Am J Ind Med. 1984; 5(4):287-95. DOI: 10.1002/ajim.4700050405. View