Malnutrition and Its Influence on Gut SIgA-Microbiota Dynamics

Overview

Journal Biomedicines

Date 2025 Jan 25

PMID 39857762

Authors

Monica Profir

Robert Mihai Enache

Oana Alexandra Rosu

Luciana Alexandra Pavelescu

Sanda Maria Cretoiu

Bogdan Severus Gaspar

Affiliations

Soon will be listed here.

Abstract

In the current era, malnutrition is seen as both undernutrition and overweight and obesity; both conditions are caused by nutrient deficiency or excess and improper use or imbalance in the intake of macro and micronutrients. Recent evidence suggests that malnutrition alters the intestinal microbiota, known as dysbiosis. Secretory immunoglobulin A (sIgA) plays an important role in maintaining and increasing beneficial intestinal microbiota populations and protecting against pathogenic species. Depletion of beneficial bacterial populations throughout life is also conditioned by malnutrition. This review aims to synthesize the evidence that establishes an interrelationship between diet, malnutrition, changes in the intestinal flora, and sIgA levels. Targeted nutritional therapies combined with prebiotic, probiotic, and postbiotic administration can restore the immune response in the intestine and the host's homeostasis.

References

Lee T, Clavel T, Smirnov K, Schmidt A, Lagkouvardos I, Walker A . Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2016; 66(5):863-871. PMC: 5531225. DOI: 10.1136/gutjnl-2015-309940. View

Mantis N, Forbes S . Secretory IgA: arresting microbial pathogens at epithelial borders. Immunol Invest. 2010; 39(4-5):383-406. PMC: 3774547. DOI: 10.3109/08820131003622635. View

Weichhart T, Hengstschlager M, Linke M . Regulation of innate immune cell function by mTOR. Nat Rev Immunol. 2015; 15(10):599-614. PMC: 6095456. DOI: 10.1038/nri3901. View

Ridaura V, Faith J, Rey F, Cheng J, Duncan A, Kau A . Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013; 341(6150):1241214. PMC: 3829625. DOI: 10.1126/science.1241214. View

Sharma S, Tripathi P . Gut microbiome and type 2 diabetes: where we are and where to go?. J Nutr Biochem. 2018; 63:101-108. DOI: 10.1016/j.jnutbio.2018.10.003. View

Yang L, Poles M, Fisch G, Ma Y, Nossa C, Phelan J . HIV-induced immunosuppression is associated with colonization of the proximal gut by environmental bacteria. AIDS. 2016; 30(1):19-29. PMC: 4813506. DOI: 10.1097/QAD.0000000000000935. View

Rytter M, Kolte L, Briend A, Friis H, Christensen V . The immune system in children with malnutrition--a systematic review. PLoS One. 2014; 9(8):e105017. PMC: 4143239. DOI: 10.1371/journal.pone.0105017. View

Iddrisu I, Monteagudo-Mera A, Poveda C, Pyle S, Shahzad M, Andrews S . Malnutrition and Gut Microbiota in Children. Nutrients. 2021; 13(8). PMC: 8401185. DOI: 10.3390/nu13082727. View

Fusco W, Lorenzo M, Cintoni M, Porcari S, Rinninella E, Kaitsas F . Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota. Nutrients. 2023; 15(9). PMC: 10180739. DOI: 10.3390/nu15092211. View

10.

Cornejo-Pareja I, Munoz-Garach A, Clemente-Postigo M, Tinahones F . Importance of gut microbiota in obesity. Eur J Clin Nutr. 2018; 72(Suppl 1):26-37. DOI: 10.1038/s41430-018-0306-8. View

11.

Biesalski H . Nutrition meets the microbiome: micronutrients and the microbiota. Ann N Y Acad Sci. 2016; 1372(1):53-64. DOI: 10.1111/nyas.13145. View

12.

Dominguez-Bello M, De Jesus-Laboy K, Shen N, Cox L, Amir A, Gonzalez A . Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer. Nat Med. 2016; 22(3):250-3. PMC: 5062956. DOI: 10.1038/nm.4039. View

13.

Zoghi S, Sadeghpour Heravi F, Nikniaz Z, Shirmohamadi M, Moaddab S, Ebrahimzadeh Leylabadlo H . Gut microbiota and childhood malnutrition: Understanding the link and exploring therapeutic interventions. Eng Life Sci. 2024; 24(5):2300070. PMC: 11065333. DOI: 10.1002/elsc.202300070. View

14.

Heiman M, Greenway F . A healthy gastrointestinal microbiome is dependent on dietary diversity. Mol Metab. 2016; 5(5):317-320. PMC: 4837298. DOI: 10.1016/j.molmet.2016.02.005. View

15.

Tourkochristou E, Triantos C, Mouzaki A . The Influence of Nutritional Factors on Immunological Outcomes. Front Immunol. 2021; 12:665968. PMC: 8201077. DOI: 10.3389/fimmu.2021.665968. View

16.

Zheng D, Liwinski T, Elinav E . Interaction between microbiota and immunity in health and disease. Cell Res. 2020; 30(6):492-506. PMC: 7264227. DOI: 10.1038/s41422-020-0332-7. View

17.

Magnusdottir S, Ravcheev D, de Crecy-Lagard V, Thiele I . Systematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes. Front Genet. 2015; 6:148. PMC: 4403557. DOI: 10.3389/fgene.2015.00148. View

18.

Turnbaugh P, Ley R, Mahowald M, Magrini V, Mardis E, Gordon J . An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122):1027-31. DOI: 10.1038/nature05414. View

19.

Sayin S, Wahlstrom A, Felin J, Jantti S, Marschall H, Bamberg K . Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013; 17(2):225-35. DOI: 10.1016/j.cmet.2013.01.003. View

20.

Medgyesi D, Sewell D, Senesac R, Cumming O, Mumma J, Baker K . The landscape of enteric pathogen exposure of young children in public domains of low-income, urban Kenya: The influence of exposure pathway and spatial range of play on multi-pathogen exposure risks. PLoS Negl Trop Dis. 2019; 13(3):e0007292. PMC: 6453472. DOI: 10.1371/journal.pntd.0007292. View