Regulation of Innate Immune Cell Function by MTOR

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2015 Sep 26

PMID 26403194

Citations 414

Authors

Thomas Weichhart

Markus Hengstschlager

Monika Linke

Affiliations

Soon will be listed here.

Abstract

The innate immune system is central for the maintenance of tissue homeostasis and quickly responds to local or systemic perturbations by pathogenic or sterile insults. This rapid response must be metabolically supported to allow cell migration and proliferation and to enable efficient production of cytokines and lipid mediators. This Review focuses on the role of mammalian target of rapamycin (mTOR) in controlling and shaping the effector responses of innate immune cells. mTOR reconfigures cellular metabolism and regulates translation, cytokine responses, antigen presentation, macrophage polarization and cell migration. The mTOR network emerges as an integrative rheostat that couples cellular activation to the environmental and intracellular nutritional status to dictate and optimize the inflammatory response. A detailed understanding of how mTOR metabolically coordinates effector responses by myeloid cells will provide important insights into immunity in health and disease.

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