Metrnl and Cardiomyopathies: From Molecular Mechanisms to Therapeutic Insights

Overview

Journal J Cell Mol Med

Date 2025 Jan 24

PMID 39853716

Authors

Miaomiao Xu

Xiaoguang Liu

Liming Lu

Zhaowei Li

Affiliations

Soon will be listed here.

Abstract

Cardiomyopathies, a diverse group of diseases affecting the heart muscle, continue to pose significant clinical challenges due to their complex aetiologies and limited treatment options targeting underlying genetic and molecular dysregulations. Emerging evidence indicates that Metrnl, a myokine, adipokine and cardiokine, plays a significant role in the pathogenesis of various cardiomyopathies. Therefore, the objective of this review is to examine the role and mechanism of Metrnl in various cardiomyopathies, with the expectation of providing new insights for the treatment of these diseases.

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