Cultured Chinese Giant Salamander Skin and Skin Secretions As a Source of Bioactive Peptides for Food and Medicine

Overview

Journal Food Sci Anim Resour

Date 2025 Jan 22

PMID 39840243

Authors

Jinghua Wang

Yuchen Liu

Hongfei Guo

Dejing Chen

Hassan Idris Abdu

Meng Yang

Jinjin Pei

A M Abd El-Aty

Affiliations

Soon will be listed here.

Abstract

Amphibians are enjoyable globally for their culinary value and are increasingly considered alternative protein sources. However, the skin of edible amphibians, especially giant salamanders, is often discarded without much thought. However, this underutilized resource holds significant potential for yielding valuable proteins and bioactive peptides (BPs). These peptides, such as brevinins, bombesins, dermaseptins, esculentins, magainins, temporins, tigerinins, and salamandrins, possess a wide range of biological activities, including antioxidant, antimicrobial, anticancer, and antidiabetic properties. This review provides a comprehensive analysis of the various BPs derived from giant salamander skin or secretions and their associated biological functions. Furthermore, it examines the nutritional composition of giant salamanders, their production status, and the challenges surrounding the use of their skin and secretions. This review also explores the potential applications of these BPs in the food and biomedical industries, particularly as multifunctional food additives, dietary supplements, and drug delivery agents.

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