A Melanoma Brain Metastasis CTC Signature and CTC:B-cell Clusters Associate with Secondary Liver Metastasis: A Melanoma Brain-Liver Metastasis Axis

Overview

Journal Cancer Res Commun

Date 2025 Jan 20

PMID 39831781

Authors

Tetiana Y Bowley

Mireya C Ortiz

Irina V Lagutina

Mara P Steinkamp

Bridget N Fahy

Bernard Tawfik

Moises Harari-Turquie

Dario Marchetti

Affiliations

Soon will be listed here.

Abstract

This study provides important insights into the relevance of prometastatic CTC:B-cell clusters in melanoma progression, extends the importance of the CTC RPL/RPS gene signature beyond primary metastasis/melanoma brain metastasis driving targeted organ specificity for liver metastasis ("metastasis of metastasis"), and identifies new targets for clinical melanoma metastasis therapies.

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