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Passive Transfer of Patient-derived Anti-nephrin Autoantibodies Causes a Podocytopathy with Minimal Change Lesions

Overview
Journal J Clin Invest
Date 2025 Jan 17
PMID 39820038
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References
1.
Watts A, Keller K, Lerner G, Rosales I, Collins A, Sekulic M . Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology. J Am Soc Nephrol. 2021; 33(1):238-252. PMC: 8763186. DOI: 10.1681/ASN.2021060794. View

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Shirai Y, Miura K, Ishizuka K, Ando T, Kanda S, Hashimoto J . A multi-institutional study found a possible role of anti-nephrin antibodies in post-transplant focal segmental glomerulosclerosis recurrence. Kidney Int. 2023; 105(3):608-617. DOI: 10.1016/j.kint.2023.11.022. View

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Seifert L, Riecken K, Zahner G, Hambach J, Hagenstein J, Dubberke G . An antigen-specific chimeric autoantibody receptor (CAAR) NK cell strategy for the elimination of anti-PLA2R1 and anti-THSD7A antibody-secreting cells. Kidney Int. 2024; 105(4):886-889. DOI: 10.1016/j.kint.2024.01.021. View

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Hengel F, Dehde S, Lasse M, Zahner G, Seifert L, Schnarre A . Autoantibodies Targeting Nephrin in Podocytopathies. N Engl J Med. 2024; 391(5):422-433. DOI: 10.1056/NEJMoa2314471. View