Altered Cytokine Production in Patients with Infection

Overview

Journal Middle East J Dig Dis

Date 2025 Jan 14

PMID 39807418

Authors

Abdollah Safikhani Mahmoodzadeh

Elham Moazamian

Seyedeh Azra Shamsdin

Gholam Abas Kaydani

Affiliations

Soon will be listed here.

Abstract

Background: is a gram-negative pathogen. The infection caused by this pathogen may result in gastritis and can increase the risk of gastric cancer. This study investigated the relationship between infection as the main risk factor for gastritis and changes in serum inflammatory cytokine levels.

Methods: Blood samples from 85 patients with stomach pain, including 46 -positive (Hp) and 39 H. pylori-negative (Hp) cases, were collected and referred to a gastroenterologist. After isolation and identification of , the severity of gastritis was determined for each patient based on the histopathological findings. Finally, the serum levels of cytokines were measured using the multiplex kit and flow cytometry methods.

Results: There were significant differences in the levels of interleukin-2 (IL-2), IL-4, IL-17A, IL-17F, IL-22, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) between the Hp and the Hp specimens (≤0.05). The levels of IL-2, IL-17A, IL-17F, IL-22, TNF-α, and IFN-γ were significantly higher in patients with mild and moderate gastritis than Hp group (≤0.05). In addition, IL-4 significantly increased in patients with moderate gastritis compared with Hp individuals (=0.008).

Conclusion: Among the inflammatory cytokines evaluated in this study, IL-17A, IL-17F, and IL-22 may play a crucial role in developing moderate gastritis in infected patients with .

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