Deterministic Patterns in Single-cell Transcriptomic Data

Overview

Journal NPJ Syst Biol Appl

Date 2025 Jan 11

PMID 39799124

Authors

Zhixing Cao

Yiling Wang

Ramon Grima

Affiliations

Soon will be listed here.

Abstract

We report the existence of deterministic patterns in statistical plots of single-cell transcriptomic data. We develop a theory showing that the patterns are neither artifacts introduced by the measurement process nor due to underlying biological mechanisms. Rather they naturally emerge from finite sample size effects. The theory precisely predicts the patterns in data from multiplexed error-robust fluorescence in situ hybridization and five different types of single-cell sequencing platforms.

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