The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL

Overview

Journal Int J Mol Sci

Publisher MDPI

Date 2025 Jan 11

PMID 39796273

Authors

Jose C Nicolau

Talia F Dalcoquio

Roberto R Giraldez

Fatima R Freitas

Andre M Nicolau

Remo H M Furtado

Thauany M Tavoni

Luciano M Baracioli

Felipe G Lima

Aline G Ferrari

Maria U P B Rondon

Rocio Salsoso

Maria J N N Alves

Flavia B B Arantes

Mayara A Santos

Leandro S Alves

Carlos E Negrao

Raul C Maranhao

Affiliations

Soon will be listed here.

Abstract

High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise is an important tool to improve prognosis in the post-infarction (MI) population, but the role of exercise on HDL functionality is poorly understood. Sixty-two patients with acute MI were randomized in a supervised exercise program for 12-14 weeks (exercise group-EG) or a control group (CG). The main objective of the study was to analyze the role of exercise on esterified cholesterol (EC) and unesterified cholesterol (UC) transfer to HDL. For the total population, the baseline mean rate of EC transfer to HDL was 2.53 ± 0.83 and at the end of follow-up, it was 2.74 ± 0.64 ( = 0.03). The figures for UC were, respectively, 4.08 ± 1.2 and 4.4 ± 1.06 ( = 0.02). The difference (follow-up minus baseline) for EC was 0.15 ± 0.84 for the control group and 0.27 ± 0.69 for the exercise group ( = 0.53); for UC, the figures were 0.28 ± 1.14 and 0.35 ± 0.96 ( = 0.80), respectively, for the control and exercise groups. In post-MI patients, 12-14 weeks of supervised exercise did not improve HDL functionality.

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