Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single-Component Organic Phototherapeutic Agents

Overview

Journal Adv Sci (Weinh)

Date 2025 Jan 10

PMID 39792832

Authors

Laiping Fang

Zengzhen Chen

Jianan Dai

Yujin Pan

Yike Tu

Qi Meng

Yanzhao Diao

Shuaibo Yang

Wei Guo

Liming Li

Jinwu Liu

Hua Wen

Kelei Hua

Lifeng Hang

Jin Fang

Xianwei Meng

Pingan Ma

Guihua Jiang

Affiliations

Soon will be listed here.

Abstract

Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single-component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, and enhanced reproducibility. Nonetheless, how to further improve the therapeutic effectiveness of SCOPAs remains a challenging research area. This review delves deeply into strategies to improve the performance of PDT or PTT by optimizing the structural design of SCOPAs. These strategies encompass augmenting reactive oxygen species (ROS) generation, mitigating oxygen dependence, elevating light absorption capacity, broadening the absorption region, and enhancing the photothermal conversion efficiency (PCE). Additionally, this review also underscores the ideal strategies for developing SCOPAs with balanced PDT and PTT. Furthermore, the potential synergies are highlighted between PDT and PTT with other treatment modalities such as ferroptosis, gas therapy, chemotherapy, and immunotherapy. By providing a comprehensive analysis of these strategies, this review aspires to serve as a valuable resource for clinicians and researchers, facilitating the wider application and advancement of SCOPAs-mediated PDT and PTT.

Citing Articles

Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single-Component Organic Phototherapeutic Agents.

Fang L, Chen Z, Dai J, Pan Y, Tu Y, Meng Q Adv Sci (Weinh). 2025; 12(7):e2409157.

PMID: 39792832 PMC: 11831458. DOI: 10.1002/advs.202409157.

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