Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content

Overview

Journal Angew Chem Int Ed Engl

Date 2025 Jan 10

PMID 39791967

Authors

Jacopo Torrisi

Matus Chvojka

Pia Jurcek

Xinxin Zhang

Huaqiang Zeng

Vladimir Sindelar

Hennie Valkenier

Affiliations

Soon will be listed here.

Abstract

Artificial anion transporters offer a potential way to treat deficiencies in cellular anion transport of genetic origins. In contrast to the large variety of mobile anion carriers and self-assembled anion channels reported, unimolecular anion channels are less investigated. Herein, we present a unique example of a unimolecular anion channel based on a bambusuril (BU) macrocycle, a well-established anion receptor. The BU structure was expanded by appending various bile acid residues allowing a single molecule to span the membrane. Chloride transport mediated by BUs through lipid bilayers was investigated in liposomes and these studies revealed a surprisingly high dependence of the anion transport activity on the cholesterol content in the liposomal membrane.

Citing Articles

Anion Transport by Bambusuril-Bile Acid Conjugates: Drastic Effect of the Cholesterol Content.

Torrisi J, Chvojka M, Jurcek P, Zhang X, Zeng H, Sindelar V Angew Chem Int Ed Engl. 2025; 64(9):e202424754.

PMID: 39791967 PMC: 11848992. DOI: 10.1002/anie.202424754.

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