5-Carboxamide Tryptamine, a Compound with High Affinity for 5-hydroxytryptamine1 Binding Sites, Dilates Arterioles and Constricts Arteriovenous Anastomoses

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1985 Feb 1

PMID 3978321

Citations 21

Authors

P R Saxena

P D Verdouw

Affiliations

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Abstract

The effects of 5-carboxamide tryptamine, which activates non-5-hydroxytryptamine2-'atypical' receptors for 5-hydroxytryptamine (5-HT) in the dog saphenous vein, was studied on the complete distribution of cardiac output and common carotid blood flow in anaesthetized pigs. The drug was infused for 10 min at the rate of 0.025, 0.1 and 0.4 micrograms kg-1 min-1 either intravenously (cardiac output distribution) or intra-arterially (carotid distribution). 5-Carboxamide tryptamine decreased arterial blood pressure due to a reduction of cardiac output. This reduction was confined to its arteriovenous anastomotic component; the component used for the tissue perfusion (nutrient part) in fact increased. Similar changes were observed in the carotid blood flow distribution. Vasodilation was observed in several tissues, but the skin, ears and stomach responded most prominently. The effects of 5-carboxamide tryptamine on the carotid distribution were not significantly modified by cyproheptadine (1 mg kg-1). It is concluded that, like 5-HT, 5-carboxamide tryptamine constricts arteriovenous anastomoses and dilates arterioles by activating non-5-HT2-'atypical' receptors. These 'atypical' 5-HT receptors appear to be of the 5-HT1 type since both 5-carboxamide tryptamine and BEA 1654, a new piperazine derivative, produced similar vascular effects in the carotid bed of the pig and also showed a high and selective affinity for the 5-HT1 binding sites.

Citing Articles

Canine renovascular responses to sumatriptan and 5-carboxamidotryptamine: modulation through endothelial 5-HT1-like receptors by endogenous nitric oxide.

Whiting M, Cambridge D Br J Pharmacol. 1995; 114(5):969-74.

PMID: 7780652 PMC: 1510329. DOI: 10.1111/j.1476-5381.1995.tb13299.x.

Vascular 5-HT1-like receptors mediating vasoconstriction and vasodilatation: their characterization and distribution in the intact canine cardiovascular system.

Cambridge D, Whiting M, BUTTERFIELD L, Marston C Br J Pharmacol. 1995; 114(5):961-8.

PMID: 7780651 PMC: 1510314. DOI: 10.1111/j.1476-5381.1995.tb13298.x.

An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney. Apparent distinction from the 5-HT1A, 5-HT1B and 5-HT1C subtypes.

Charlton K, Bond R, Clarke D Naunyn Schmiedebergs Arch Pharmacol. 1986; 332(1):8-15.

PMID: 3951568 DOI: 10.1007/BF00633190.

Effects of MDL 72222 and methiothepin on carotid vascular responses to 5-hydroxytryptamine in the pig: evidence for the presence of "5-hydroxytryptamine1-like" receptors.

Saxena P, Duncker D, Bom A, Heiligers J, Verdouw P Naunyn Schmiedebergs Arch Pharmacol. 1986; 333(3):198-204.

PMID: 3762734 DOI: 10.1007/BF00512930.

5-Hydroxytryptamine-induced tachycardia in the pig: possible involvement of a new type of 5-hydroxytryptamine receptor.

Bom A, Duncker D, Saxena P, Verdouw P Br J Pharmacol. 1988; 93(3):663-71.

PMID: 3370393 PMC: 1853857. DOI: 10.1111/j.1476-5381.1988.tb10324.x.

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