Integrating Natural Product Research Laboratory with Artificial Intelligence: Advancements and Breakthroughs in Traditional Medicine

Overview

Journal Biomedicine (Taipei)

Date 2025 Jan 8

PMID 39777110

Authors

Jai-Sing Yang

Shih-Chang Tsai

Yuan-Man Hsu

DA-Tian Bau

Chia-Wen Tsai

Wen-Shin Chang

Sheng-Chu Kuo

Chien-Chih Yu

Yu-Jen Chiu

Fuu-Jen Tsai

Affiliations

Soon will be listed here.

Abstract

The Natural Product Research Laboratory (NPRL) of China Medical University Hospital (CMUH) was established in collaboration with CMUH and Professor Kuo-Hsiung Lee from the University of North Carolina at Chapel Hill. The laboratory collection features over 6000 natural products worldwide, including pure compounds and semi-synthetic derivatives. This is the most comprehensive and fully operational natural product database in Taiwan. This review article explores the history and development of the NPRL of CMUH. We then provide an overview of the recent applications and impact of artificial intelligence (AI) in new drug discovery. Finally, we examine advanced powerful AI-tools and related software to explain how these resources can be utilized in research on large-scale drug data libraries. This article presents a drug research and development (R&D) platform that combines AI with the NPRL. We believe that this approach will reduce resource wastage and enhance the research capabilities of Taiwan's academic and industrial sectors in biotechnology and pharmaceuticals.

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