Green Tea Consumption and Cerebral White Matter Lesions in Community-dwelling Older Adults Without Dementia

Overview

Journal NPJ Sci Food

Publisher Springer Nature

Date 2025 Jan 8

PMID 39774601

Authors

Shutaro Shibata

Moeko Noguchi-Shinohara

Ayano Shima

Taro Ozaki

Yuta Usui

Yasuyuki Taki

Kazuhiro Uchida

Takanori Honda

Jun Hata

Tomoyuki Ohara

Tatsuya Mikami

Tetsuya Maeda

Masaru Mimura

Kenji Nakashima

Jun-Ichi Iga

Minoru Takebayashi

Toshiharu Ninomiya

Kenjiro Ono

Affiliations

Soon will be listed here.

Abstract

This study investigated the association between green tea or coffee consumption with cerebral white matter lesions and hippocampal and total brain volumes among 8766 community-dwelling participants recruited from the Japan Prospective Studies Collaboration for Aging and Dementia between 2016 and 2018. A Food Frequency Questionnaire was used to assess green tea and coffee consumption, whereas brain magnetic resonance imaging was performed to assess cerebral white matter lesions, hippocampal volume, and total brain volume. Multivariable-adjusted analysis revealed significant correlations between fewer cerebral white matter lesions and higher green tea consumption, whereas no significant differences were found between green tea consumption and hippocampal or total brain volume. Regarding coffee consumption, no significant differences were observed in cerebral white matter lesions or hippocampal or total brain volumes. Hence, higher green tea consumption was associated with fewer cerebral white matter lesions, suggesting that it may be useful in preventing dementia.

References

Levites Y, Amit T, Mandel S, Youdim M . Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallate. FASEB J. 2003; 17(8):952-4. DOI: 10.1096/fj.02-0881fje. View

Liu Q, Wu Y, Cheng H, Xia T, Ding H, Wang H . Habitual coffee consumption and risk of cognitive decline/dementia: A systematic review and meta-analysis of prospective cohort studies. Nutrition. 2016; 32(6):628-36. DOI: 10.1016/j.nut.2015.11.015. View

Ehrnhoefer D, Bieschke J, Boeddrich A, Herbst M, Masino L, Lurz R . EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers. Nat Struct Mol Biol. 2008; 15(6):558-66. DOI: 10.1038/nsmb.1437. View

Mahdavi-Roshan M, Salari A, Ghorbani Z, Ashouri A . The effects of regular consumption of green or black tea beverage on blood pressure in those with elevated blood pressure or hypertension: A systematic review and meta-analysis. Complement Ther Med. 2020; 51:102430. DOI: 10.1016/j.ctim.2020.102430. View

Jack Jr C, Bernstein M, Fox N, Thompson P, Alexander G, Harvey D . The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging. 2008; 27(4):685-91. PMC: 2544629. DOI: 10.1002/jmri.21049. View

Fraser M, Mok G, Lee A . Green tea and stroke prevention: emerging evidence. Complement Ther Med. 2007; 15(1):46-53. DOI: 10.1016/j.ctim.2006.07.002. View

Moore R, Jackson K, Minihane A . Green tea (Camellia sinensis) catechins and vascular function. Br J Nutr. 2009; 102(12):1790-802. DOI: 10.1017/S0007114509991218. View

Habes M, Erus G, Toledo J, Zhang T, Bryan N, Launer L . White matter hyperintensities and imaging patterns of brain ageing in the general population. Brain. 2016; 139(Pt 4):1164-79. PMC: 5006227. DOI: 10.1093/brain/aww008. View

Sugiyama K, Tomata Y, Kaiho Y, Honkura K, Sugawara Y, Tsuji I . Association between Coffee Consumption and Incident Risk of Disabling Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study. J Alzheimers Dis. 2015; 50(2):491-500. DOI: 10.3233/JAD-150693. View

10.

Leung L, Su Y, Chen R, Zhang Z, Huang Y, Chen Z . Theaflavins in black tea and catechins in green tea are equally effective antioxidants. J Nutr. 2001; 131(9):2248-51. DOI: 10.1093/jn/131.9.2248. View

11.

Molino S, Dossena M, Buonocore D, Ferrari F, Venturini L, Ricevuti G . Polyphenols in dementia: From molecular basis to clinical trials. Life Sci. 2016; 161:69-77. DOI: 10.1016/j.lfs.2016.07.021. View

12.

Ano Y, Ohya R, Kita M, Taniguchi Y, Kondo K . Theaflavins Improve Memory Impairment and Depression-Like Behavior by Regulating Microglial Activation. Molecules. 2019; 24(3). PMC: 6384870. DOI: 10.3390/molecules24030467. View

13.

Puzo C, Labriola C, Sugarman M, Tripodis Y, Martin B, Palmisano J . Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer's Coordinating Center Uniform Data Set. Alzheimers Res Ther. 2019; 11(1):64. PMC: 6661103. DOI: 10.1186/s13195-019-0521-0. View

14.

Shima A, Noguchi-Shinohara M, Shibata S, Usui Y, Tatewaki Y, Thyreau B . Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function. NPJ Aging. 2024; 10(1):39. PMC: 11384785. DOI: 10.1038/s41514-024-00164-2. View

15.

Nanjo F, Mori M, Goto K, Hara Y . Radical scavenging activity of tea catechins and their related compounds. Biosci Biotechnol Biochem. 1999; 63(9):1621-3. DOI: 10.1271/bbb.63.1621. View

16.

Ninomiya T, Nakaji S, Maeda T, Yamada M, Mimura M, Nakashima K . Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD). Environ Health Prev Med. 2020; 25(1):64. PMC: 7603740. DOI: 10.1186/s12199-020-00903-3. View

17.

Mayer C, Nagele F, Petersen M, Schell M, Aarabi G, Beikler T . Association between Coffee Consumption and Brain MRI Parameters in the Hamburg City Health Study. Nutrients. 2023; 15(3). PMC: 9919011. DOI: 10.3390/nu15030674. View

18.

Eskelinen M, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M . Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis. 2009; 16(1):85-91. DOI: 10.3233/JAD-2009-0920. View

19.

Noguchi-Shinohara M, Yuki S, Dohmoto C, Ikeda Y, Samuraki M, Iwasa K . Consumption of green tea, but not black tea or coffee, is associated with reduced risk of cognitive decline. PLoS One. 2014; 9(5):e96013. PMC: 4020750. DOI: 10.1371/journal.pone.0096013. View

20.

Noguchi-Shinohara M, Yuki-Nozaki S, Abe C, Mori A, Horimoto M, Yokogawa M . Diabetes Mellitus, Elevated Hemoglobin A1c, and Glycated Albumin Are Associated with the Presence of All-Cause Dementia and Alzheimer's Disease: The JPSC-AD Study. J Alzheimers Dis. 2021; 85(1):235-247. DOI: 10.3233/JAD-215153. View