Clinical Evaluation of Extract Combinations for Effective Hangover Relief in Humans

Overview

Journal Foods

Specialty Biotechnology

Date 2025 Jan 8

PMID 39766963

Authors

Ki Won Lee

Guangpeng Xu

Dong Hyun Paik

Youn Young Shim

Martin J T Reaney

Ilbum Park

Sang-Hun Lee

Jong-Yul Park

Euddeum Park

Sung-Bum Lee

In Ah Kim

Ji Youn Hong

Young Jun Kim

Affiliations

Soon will be listed here.

Abstract

Alcohol consumption is associated with both short- and long-term adverse effects, including hangover symptoms. The objective of this study was to examine the potential benefits of traditional beverages containing a combination of extract (HD) with either extract (HDPB) or glutathione yeast extract (HDGB) in abbreviating alcohol intoxication and mitigating hangover symptoms. A total of 25 participants between the ages of 19 and 40 who had previously experienced a hangover were evaluated in a randomized, double-blind, crossover, placebo (PLA)-controlled clinical trial. Results showed that lower blood alcohol concentrations in the HDPB and HDGB groups were significantly lower than in the PLA group at 0.25 and 0.5 h, suggesting that HD aids in early alcohol metabolism (0 h, < 0.05). Analysis of the hourly Acute Hangover Scale (AHS) showed that all treatment groups had significantly reduced gastrointestinal disorder symptoms compared to the PLA group ( < 0.05). It can be confirmed that hangover symptoms can be significantly improved by consuming HD combination drinks, apart from the effect of reducing blood alcohol and acetaldehyde concentrations. Therefore, it is predicted that the consumption of natural phytochemicals added to HD is safe for humans and may help accelerate recovery from hangover symptoms.

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