Mechanisms, Machinery, and Dynamics of Chromosome Segregation in

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2025 Jan 8

PMID 39766873

Authors

Marissa E Duffy

Michael Ngaw

Shayna E Polsky

Abby E Marzec

Sean S Zhang

Owen R Dzierzgowski

Natalie J Nannas

Affiliations

Soon will be listed here.

Abstract

(maize) is both an agronomically important crop and a powerful genetic model system with an extensive molecular toolkit and genomic resources. With these tools, maize is an optimal system for cytogenetic study, particularly in the investigation of chromosome segregation. Here, we review the advances made in maize chromosome segregation, specifically in the regulation and dynamic assembly of the mitotic and meiotic spindle, the inheritance and mechanisms of the abnormal chromosome variant Ab10, the regulation of chromosome-spindle interactions via the spindle assembly checkpoint, and the function of kinetochore proteins that bridge chromosomes and spindles. In this review, we discuss these processes in a species-specific context including features that are both conserved and unique to . Additionally, we highlight new protein structure prediction tools and make use of these tools to identify several novel kinetochore and spindle assembly checkpoint proteins in .

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