Fluorescent "on-off-on" Sensor Based on N, P Co-doped Carbon Nanoparticles for Specific Detection of Fe and Ascorbic Acid

Overview

Journal J Food Drug Anal

Specialties Nutritional Sciences
Pharmacology
Toxicology

Date 2025 Jan 3

PMID 39752858

Authors

Li Li

Ming Zhang

Xiang Liu

Shaoqing Zhu

Affiliations

Soon will be listed here.

Abstract

Ascorbic acid (AA) is used as a food additive for its antibacterial and antioxidant properties. However, excessive intake of AA is harmful to humans. Therefore, the detection of Fe and AA is generally recognized to be meaningful. In this work, a one-step hydrothermal tactics is developed for the preparing nitrogen and phosphorus co-doped carbon nanoparticles (N, P-CNPs) by using sucrose and ammonium orthophosphate as raw materials. The N, P-CNPs not only exhibited an enhanced fluorescent efficiency with a relatively high quantum yield up to 28%, but also showed satisfactory stability, water solubility and photostability. The fluorescence of N, P-CNPs can be effectively quenched by Fe by a combination of inner filter effect (IFE) and static quenching and recovered upon the addition of AA due to the easy conversion of Fe to reduced states Fe by AA. Therefore, a turn-off-on fluorescent sensing strategy can be constructed for sequential detection of Fe and AA with detection limits of 0.03 μM and 6 nM with the corresponding linear ranges of 0.05-500 μM and 0.01-500 μM respectively. The proposed fluorescent sensor exhibits excellent sensing performance and has been applied to the determination of Fe in tap water and the analyses of AA in canned fruit soup with satisfactory results. Therefore, this fluorescent sensor expressed high potential in water quality monitoring, and could be further used to be a tool for practical food additives detection.

References

Lo K, Lin Y, Liou J, Chiu T, Hu C . Electrochemically synthesized green fluorescent carbon dots for quantitation of hypochlorite and carbendazim. J Food Drug Anal. 2023; 31(2):244-253. PMC: 10281730. DOI: 10.38212/2224-6614.3445. View

Redondo-Fernandez G, Cigales Canga J, Soldado A, Encinar J, Costa-Fernandez J . Functionalized heteroatom-doped carbon dots for biomedical applications: A review. Anal Chim Acta. 2023; 1284:341874. DOI: 10.1016/j.aca.2023.341874. View

Song S, Liang F, Li M, Du F, Dong W, Gong X . A label-free nano-probe for sequential and quantitative determination of Cr(VI) and ascorbic acid in real samples based on S and N dual-doped carbon dots. Spectrochim Acta A Mol Biomol Spectrosc. 2019; 215:58-68. DOI: 10.1016/j.saa.2019.02.065. View

Li X, Wang C, Li P, Sun X, Shao Z, Xia J . Beer-derived nitrogen, phosphorus co-doped carbon quantum dots: Highly selective on-off-on fluorescent probes for the detection of ascorbic acid in fruits. Food Chem. 2022; 409:135243. DOI: 10.1016/j.foodchem.2022.135243. View

Chen B, Liu M, Li C, Huang C . Fluorescent carbon dots functionalization. Adv Colloid Interface Sci. 2019; 270:165-190. DOI: 10.1016/j.cis.2019.06.008. View

Zhao Y, Zhu X, Liu L, Duan Z, Liu Y, Zhang W . One-Step Synthesis of Nitrogen/Fluorine Co-Doped Carbon Dots for Use in Ferric Ions and Ascorbic Acid Detection. Nanomaterials (Basel). 2022; 12(14). PMC: 9323265. DOI: 10.3390/nano12142377. View

Xu O, Wan S, Yang J, Song H, Dong L, Xia J . Ni-MOF Functionalized Carbon Dots with Fluorescence and Adsorption Performance for Rapid Detection of Fe (III) and Ascorbic Acid. J Fluoresc. 2022; 32(5):1743-1754. DOI: 10.1007/s10895-022-02982-7. View

Du F, Gong X, Lu W, Liu Y, Gao Y, Shuang S . Bright-green-emissive nitrogen-doped carbon dots as a nanoprobe for bifunctional sensing, its logic gate operation and cellular imaging. Talanta. 2018; 179:554-562. DOI: 10.1016/j.talanta.2017.11.030. View

Sudewi S, Chabib L, Zulfajri M, Gedda G, Huang G . Polyvinylpyrrolidone-passivated fluorescent iron oxide quantum dots for turn-off detection of tetracycline in biological fluids. J Food Drug Anal. 2023; 31(1):177-193. PMC: 10208663. DOI: 10.38212/2224-6614.3440. View

10.

Dong W, Yu J, Gong X, Liang W, Fan L, Dong C . A turn-off-on near-infrared photoluminescence sensor for sequential detection of Fe and ascorbic acid based on glutathione-capped gold nanoclusters. Spectrochim Acta A Mol Biomol Spectrosc. 2020; 247:119085. DOI: 10.1016/j.saa.2020.119085. View

11.

Wang R, Wang Y, Zhao N, Zhao H, Yuan X, Zhao L . Nitrogen and Sulfur Co-doped Carbon Quantum Dots for Detecting Fe, Ascorbic Acid and Alkaline Phosphatase Activities. J Fluoresc. 2023; 35(1):445-458. DOI: 10.1007/s10895-023-03539-y. View

12.

Wang M, Wan Y, Zhang K, Fu Q, Wang L, Zeng J . Green synthesis of carbon dots using the flowers of Osmanthus fragrans (Thunb.) Lour. as precursors: application in Fe and ascorbic acid determination and cell imaging. Anal Bioanal Chem. 2019; 411(12):2715-2727. DOI: 10.1007/s00216-019-01712-6. View

13.

Wang M, Liu M, Nong S, Song W, Zhang X, Shen S . Highly Luminescent Nucleoside-Based N, P-Doped Carbon Dots for Sensitive Detection of Ions and Bioimaging. Front Chem. 2022; 10:906806. PMC: 9210210. DOI: 10.3389/fchem.2022.906806. View

14.

Zhan Y, Chiu C, Chen Y . Using lanthanide ions as magnetic and sensing probes for the detection of tetracycline from complex samples. J Food Drug Anal. 2023; 31(2):371-380. PMC: 10281728. DOI: 10.38212/2224-6614.3457. View

15.

Lai W, Guo J, Zheng N, Nie Y, Ye S, Tang D . Selective determination of 2,4,6-trinitrophenol by using a novel carbon nanoparticles as a fluorescent probe in real sample. Anal Bioanal Chem. 2020; 412(13):3083-3090. DOI: 10.1007/s00216-020-02558-z. View

16.

Li Z, Tan B, Wu Z, Huang X . A Robust Strontium Coordination Polymer with Selective and Sensitive Fluorescence Sensing Ability for Fe Ions. Materials (Basel). 2023; 16(2). PMC: 9866177. DOI: 10.3390/ma16020577. View

17.

Zuo P, Zhang J, Zhou Y, Xie N, Xiao D . Spontaneous Formation of Fluorescent Carbon Nanoparticles in Glutaraldehyde Solution and Their Fluorescence Mechanism. J Fluoresc. 2021; 31(2):509-516. DOI: 10.1007/s10895-020-02678-w. View

18.

Guo X, Yue G, Huang J, Liu C, Zeng Q, Wang L . Label-Free Simultaneous Analysis of Fe(III) and Ascorbic Acid Using Fluorescence Switching of Ultrathin Graphitic Carbon Nitride Nanosheets. ACS Appl Mater Interfaces. 2018; 10(31):26118-26127. DOI: 10.1021/acsami.8b10529. View

19.

Luo X, Zhang W, Han Y, Chen X, Zhu L, Tang W . N,S co-doped carbon dots based fluorescent "on-off-on" sensor for determination of ascorbic acid in common fruits. Food Chem. 2018; 258:214-221. DOI: 10.1016/j.foodchem.2018.03.032. View

20.

Yoo D, Park Y, Cheon B, Park M . Carbon Dots as an Effective Fluorescent Sensing Platform for Metal Ion Detection. Nanoscale Res Lett. 2019; 14(1):272. PMC: 6692426. DOI: 10.1186/s11671-019-3088-6. View