RamA Upregulates the ATP-binding Cassette Transporter to Mediate Resistance to Tetracycline-class Antibiotics and the Stability of Membranes in

Overview

Journal Microbiol Spectr

Specialty Microbiology

Date 2025 Jan 2

PMID 39745369

Authors

Xiaoyu Zhao

Yixin Zhang

Mohan Ju

Yang Yang

Haoqi Liu

Xiaohua Qin

Qingqing Xu

Min Hao

Affiliations

Soon will be listed here.

Abstract

Importance: Multidrug-resistant and extensively drug-resistant have emerged as significant global health concerns resulting in high mortality rates. Although previous research has investigated the maintenance of lipid asymmetry (Mla) pathway, the extent to which it mediates antimicrobial resistance in and the underlying upstream regulatory mechanisms remain unclear. In this study, we sought to determine at the molecular level how the AraC-type global regulator RamA directly regulates mlaFEDCB, which mediates resistance to tetracycline-class antibiotics and the stability of bacterial membranes in .

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