Regulatory Effects of HBUAS52074 on Depression-like Behavior Induced by Chronic Social Defeat Stress in Mice: Modulation of the Gut Microbiota

The gut microbiome has emerged as a growing focus of research and public health interest, leading to the frequent exploration of probiotic dietary supplements as potential treatments for various disorders, such as anxiety and depression. In the present report, changes in inflammation and microbiome composition were assessed in model mice exhibiting depressive-like behaviors that were exposed to the probiotic HBUAS52074. It was found that HBUAS52074 alleviated the severity of depressive-like behaviors while increasing serum 5-HT concentrations. Moreover, HBUAS52074 modulated the composition of the gut microbiota, resulting in a decrease in the abundance of and an increase in the abundance of . Additionally, supplementation with HBUAS52074 enhanced intestinal barrier function and reduced inflammation in peripheral blood, as well as in the hippocampal and prefrontal cortical tissues. Correlational analyses indicated that the abundance of was positively correlated with the social interaction ratio, time spent in the center, entries into the center, as well as serum 5-HT and serum IL-10 levels but negatively correlated with immobility time. Overall, chronic social defeat stress was found to be associated with inflammation and the exacerbation of depressive-like behaviors. The above findings suggested that HBUAS52074 supplementation was sufficient to alter the parameters. Collectively, these data suggest that HBUAS52074, derived from naturally fermented foods, may possess therapeutic potential for the treatment of depression.