Cognitive Aspects of Motor Control Deteriorate While off Treatment Following Subthalamic Nucleus Deep Brain Stimulation Surgery in Parkinson's Disease

Overview

Journal Front Neurol

Specialty Neurology

Date 2025 Jan 2

PMID 39744112

Authors

Miranda J Munoz

Rishabh Arora

Yessenia M Rivera

Quentin H Drane

Gian D Pal

Leo Verhagen Metman

Sepehr B Sani

Joshua M Rosenow

Lisa C Goelz

Daniel M Corcos

Fabian J David

Affiliations

Soon will be listed here.

Abstract

Introduction: The long-term effects of surgery for subthalamic nucleus deep brain stimulation (STN-DBS) on cognitive aspects of motor control for people with Parkinson's disease (PD) are largely unknown. We compared saccade latency and reach reaction time (RT) pre- and post-surgery while participants with PD were off-treatment.

Methods: In this preliminary study, we assessed people with PD approximately 1 month pre-surgery while OFF medication (OFF-MEDS) and about 8 months post-surgery while OFF medication and STN-DBS treatment (OFF-MEDS/OFF-DBS). We examined saccade latency and reach reaction time (RT) performance during a visually-guided reaching task requiring participants to look at and reach toward a visual target.

Results: We found that both saccade latency and reach RT significantly increased post-surgery compared to pre-surgery. In addition, there was no significant change in Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III score.

Discussion: We found detrimental post-surgical changes to saccade latency and reach RT. We discuss the potential contributions of long-term tissue changes and withdrawal from STN-DBS on this detrimental cognitive effect.

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