Autophagy Receptor-inspired Chimeras: a Novel Approach to Facilitate the Removal of Protein Aggregates and Organelle by Autophagy Degradation

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2025 Jan 1

PMID 39743298

Authors

Liwen Wang

Huimei Liu

Lanfang Li

Affiliations

Soon will be listed here.

Abstract

Neurodegenerative diseases (NDDs), mainly including Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), and Alzheimer's disease (AD), are sporadic and rare genetic disorders of the central nervous system. A key feature of these conditions is the slow accumulation of misfolded protein deposits in brain neurons, the excessive aggregation of which leads to neurotoxicity and further disorders of the nervous system.

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