Gut Commensal Barnesiella Intestinihominis Ameliorates Hyperglycemia and Liver Metabolic Disorders

Overview

Journal Adv Sci (Weinh)

Specialty Biomedical Engineering

Date 2025 Jan 1

PMID 39741391

Authors

Ye Zhang

Dong Xu

Xuyi Cai

Xue Xing

Xin Shao

Ailing Yin

Yanyan Zhao

Mengyuan Wang

Yu-Nuo Fan

Boao Liu

Hua Yang

Wei Zhou

Ping Li

Affiliations

Soon will be listed here.

Abstract

Recent studies have highlighted the role of the gut microbiota in type 2 diabetes (T2D). Improving gut microbiota dysbiosis can be a potential strategy for the prevention and management of T2D. Here, this work finds that the abundance of Barnesiella intestinihominis is significantly decreased in the fecal of T2D patients from 2-independent centers. Oral treatment of live B. intestinihominis (LBI) considerably ameliorates hyperglycemia and liver metabolic disorders in HFD/STZ-induced T2D models and db/db mice. LBI-derived acetate has similar protective effects against T2D. Mechanistically, acetate enhances fibroblast growth factor 21 (FGF21) through inhibition of histone deacetylase 9 (HDAC9) to increase H3K27 acetylation at the FGF21 promoter. The screening puerarin from Gegen Qinlian decoction in a gut microbiota-dependent manner improved hyperglycemia and liver metabolic disorders by promoting the growth of B. intestinihominis. This study suggests that gut commensal B. intestinihominis and puerarin, respectively have the potential as a probiotic and prebiotic in the treatment of T2D.

Citing Articles

Gut Commensal Barnesiella Intestinihominis Ameliorates Hyperglycemia and Liver Metabolic Disorders.

Zhang Y, Xu D, Cai X, Xing X, Shao X, Yin A Adv Sci (Weinh). 2025; 12(8):e2411181.

PMID: 39741391 PMC: 11848638. DOI: 10.1002/advs.202411181.

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