Divergent Brain Solute Clearance in Rat Models of Cerebral Amyloid Angiopathy and Alzheimer's Disease

Overview

Journal iScience

Publisher Cell Press

Date 2024 Dec 25

PMID 39720539

Authors

Sunil Koundal

Xinan Chen

Zachary Gursky

Hedok Lee

Kaiming Xu

Feng Liang

Zhongcong Xie

Feng Xu

Hung-Mo Lin

William E Van Nostrand

Xianfeng Gu

Rena Elkin

Allen Tannenbaum

Helene Benveniste

Affiliations

Soon will be listed here.

Abstract

Brain waste clearance from the interstitial fluid environment is challenging to measure, which has contributed to controversy regarding the significance of glymphatic transport impairment for neurodegenerative processes. Dynamic contrast enhanced MRI (DCE-MRI) with cerebrospinal fluid administration of Gd-tagged tracers is often used to assess glymphatic system function. We previously quantified glymphatic transport from DCE-MRI data utilizing regularized optimal mass transport (rOMT) analysis, however, information specific to glymphatic clearance was not directly derived. To fill this knowledge gap, we here implemented unbalanced rOMT analysis which allows for assessment of both influx and clearance. Dynamic influx/clearance brain maps were derived from rTg-DI rats with cerebral amyloid angiopathy (CAA) and TgSD-AD rats with Alzheimer's disease (AD). The rTg-DI rats with severe CAA disease exhibited abnormal influx/clearance kinetics, while TgSD-AD rats with a moderate Aβ plaque load exhibited normal transport suggesting that different Aβ lesions and their overall burden differentially impact glymphatic system function.

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