Molecular Mechanism of Culinary Herb Artemisia Argyi in Promoting Lifespan and Stress Tolerance

Overview

Journal NPJ Sci Food

Publisher Springer Nature

Date 2024 Dec 24

PMID 39719452

Authors

Jinsong Wang

Deyan Zhu

Hailin Cui

Yan Xu

Shuyou Shang

Yuanxin Miao

Zhimin Xu

Rong Li

Affiliations

Soon will be listed here.

Abstract

Artemisia argyi Lévl. et Vant. (A. argyi) leaf possesses various health promoting functions contributed by its main bioactive flavonoids. In this study, the anti-aging effect and mechanism of Artemisia argyi leaf extract (AALE) were identified using Caenorhabditis elegans (C. elegans) as a model. The results showed that the AALE promoted the lifespan and stress resistance of C. elegans. It was found that the AALE boosted the expression of oxidative stress-related proteins by regulating the insulin/ IGF-1 signaling (IIS) pathway, which then activated the transcription factors DAF-16/FOXO. The results of RNA-sequence analysis indicated that the changes of genes in nematodes treated with AALE were associated with the responses against oxidative stress, cell maturation, and immune reaction, and stress. The positive results suggest that Artemisia argyi leaf could have the robust benefits for improving healthy aging as well as preventing aging-related diseases in the human body.

References

Yu K, Zhang Q, Meng X, Zhang L, Kan H, Chen R . Association of residential greenness with incident chronic obstructive pulmonary disease: A prospective cohort study in the UK Biobank. Environ Int. 2022; 171:107654. DOI: 10.1016/j.envint.2022.107654. View

Shi X, Yu X, Yang L, Duan X . Ethyl acetate extract of protects from oxidative stress and amyloid β peptide toxicity. Exp Ther Med. 2023; 26(2):405. PMC: 10375435. DOI: 10.3892/etm.2023.12104. View

Lund J, Tedesco P, Duke K, Wang J, Kim S, Johnson T . Transcriptional profile of aging in C. elegans. Curr Biol. 2002; 12(18):1566-73. DOI: 10.1016/s0960-9822(02)01146-6. View

Denzel M, Lapierre L, Mack H . Emerging topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics. Mech Ageing Dev. 2018; 177:4-21. PMC: 6696993. DOI: 10.1016/j.mad.2018.08.001. View

Lu L, Shu C, Chen L, Yang Y, Ma S, Zhu K . Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Fitoterapia. 2020; 146:104687. DOI: 10.1016/j.fitote.2020.104687. View

Lee S, Won H, Ban S, Park Y, Kim S, Kim H . Integrative analysis of metabolite and transcriptome reveals biosynthetic pathway and candidate genes for eupatilin and jaceosidin biosynthesis in . Front Plant Sci. 2023; 14:1186023. PMC: 10166882. DOI: 10.3389/fpls.2023.1186023. View

Li R, Tao M, Xu T, Huang Y, Zogona D, Pan S . Artemisia selengensis Turcz. leaf extract promotes longevity and stress resistance in Caenorhabditis elegans. J Sci Food Agric. 2022; 102(11):4532-4541. DOI: 10.1002/jsfa.11808. View

Shao H, Wang D . Long-term and low-dose exposure to nanopolystyrene induces a protective strategy to maintain functional state of intestine barrier in nematode Caenorhabditis elegans. Environ Pollut. 2019; 258:113649. DOI: 10.1016/j.envpol.2019.113649. View

Wan Q, Fu X, Meng X, Luo Z, Dai W, Yang J . Hypotaurine promotes longevity and stress tolerance via the stress response factors DAF-16/FOXO and SKN-1/NRF2 in Caenorhabditis elegans. Food Funct. 2019; 11(1):347-357. DOI: 10.1039/c9fo02000d. View

10.

Asif M, Nocilla K, Ngo L, Shah M, Smadi Y, Hafeez Z . Role of UDP-Glycosyltransferase () Genes in Detoxification and Glycosylation of 1-Hydroxyphenazine (1-HP) in . Chem Res Toxicol. 2024; 37(4):590-599. PMC: 11022241. DOI: 10.1021/acs.chemrestox.3c00410. View

11.

Lee H, Lee S . Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in . Mol Cells. 2022; 45(11):763-770. PMC: 9676989. DOI: 10.14348/molcells.2022.0097. View

12.

Tao M, Li R, Zhang Z, Wu T, Xu T, Zogona D . Vitexin and Isovitexin Act through Inhibition of Insulin Receptor to Promote Longevity and Fitness in Caenorhabditis elegans. Mol Nutr Food Res. 2022; 66(17):e2100845. DOI: 10.1002/mnfr.202100845. View

13.

Tia N, Singh A, Pandey P, Azad C, Chaudhary P, Gambhir I . Role of Forkhead Box O (FOXO) transcription factor in aging and diseases. Gene. 2018; 648:97-105. DOI: 10.1016/j.gene.2018.01.051. View

14.

Walker G, White T, McColl G, Jenkins N, Babich S, Candido E . Heat shock protein accumulation is upregulated in a long-lived mutant of Caenorhabditis elegans. J Gerontol A Biol Sci Med Sci. 2001; 56(7):B281-7. DOI: 10.1093/gerona/56.7.b281. View

15.

Lapierre L, Hansen M . Lessons from C. elegans: signaling pathways for longevity. Trends Endocrinol Metab. 2012; 23(12):637-44. PMC: 3502657. DOI: 10.1016/j.tem.2012.07.007. View

16.

Kang J, Park S, Kim J, Park S, Yoo S, Han H . 4,5-dicaffeyolquinic acid improves high-fat diet-induced cognitive dysfunction through the regulation of insulin degrading enzyme. J Food Biochem. 2019; 43(7):e12855. DOI: 10.1111/jfbc.12855. View

17.

Ye Y, Gu Q, Sun X . Potential of Caenorhabditis elegans as an antiaging evaluation model for dietary phytochemicals: A review. Compr Rev Food Sci Food Saf. 2020; 19(6):3084-3105. DOI: 10.1111/1541-4337.12654. View

18.

Murphy C, McCarroll S, Bargmann C, Fraser A, Kamath R, Ahringer J . Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature. 2003; 424(6946):277-83. DOI: 10.1038/nature01789. View

19.

Li R, Yi Q, Wang J, Miao Y, Chen Q, Xu Y . Paeonol promotes longevity and fitness in Caenorhabditis elegans through activating the DAF-16/FOXO and SKN-1/Nrf2 transcription factors. Biomed Pharmacother. 2024; 173:116368. DOI: 10.1016/j.biopha.2024.116368. View

20.

Monickaraj F, Aravind S, Nandhini P, Prabu P, Sathishkumar C, Mohan V . Accelerated fat cell aging links oxidative stress and insulin resistance in adipocytes. J Biosci. 2013; 38(1):113-22. DOI: 10.1007/s12038-012-9289-0. View