Identification of Circulating Risk Biomarkers for Cognitive Decline in a Large Community-based Population in Chongqing China

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2024 Dec 23

PMID 39713874

Authors

Yu Kang

Zijuan Feng

Qian Zhang

Mingjing Liu

Yanhua Li

Huan Yang

Lingling Zheng

Chunjiang Cheng

Weitao Zhou

Dandan Lou

Xiaoyong Li

Liangping Chen

Yi Feng

Xiaoling Duan

Jianzhong Duan

Mengjiao Yu

Shou Yang

Yuhang Liu

Xin Wang

Bo Deng

Chenghui Liu

Xiuqing Yao

Chi Zhu

Chunrong Liang

Xiaolong Zeng

Sisi Ren

Qunying Li

Yin Zhong

Yong Yan

Huaqing Meng

Zhaohui Zhong

Yong Zhang

Jun Kang

Xiaoqian Luan

Sipei Pan

Yili Wu

Tingyu Li

Weihong Song

Yun Zhang

Affiliations

Soon will be listed here.

Abstract

Introduction: This study aims to investigate the relationship between blood-based pathologies and established risk factors for cognitive decline in the community-based population of Chongqing, a region with significant aging.

Methods: A total of 26,554 residents aged 50 years and older were recruited. Multinomial logistic regression models were applied to assess the risk factors of cognition levels. Propensity score matching and linear mixed effects models were used to evaluate the relationship between key risk factors and the circulating biomarkers.

Results: Shared and distinct risk factors for MCI and dementia were identified. Age, lower education, medical history of stroke, hypertension, and epilepsy influenced mild cognitive impairment (MCI) progression to dementia. Correlations between key risk factors and circulating neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), amyloid β protein (Aβ)40, and Aβ42/Aβ40 ratio suggest underlying mechanisms contributing to cognitive impairment.

Discussion: The common and distinct risk factors across cognitive decline stages emphasize the need for tailored interventions. The correlations with blood biomarkers provide insights into potential management targets.

Highlights: From a large community-based cohort study on the residents in Chongqing, we have identified that mild cognitive impairment (MCI) and dementia share several common risk factors, including age, female gender, rural living, lower education levels, and a medical history of stroke. However, each condition also has its own unique risk factors. Several factors contribute to the progression of MCI into dementia including age, education levels, occupation, and a medical history of hypertension and epilepsy. We discover the correlations between the risk factors for dementia and blood biomarkers that indicate the presence of axonal damage, glial activation, and Aβ pathology.

Citing Articles

Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China.

Kang Y, Feng Z, Zhang Q, Liu M, Li Y, Yang H Alzheimers Dement. 2024; 21(2):e14443.

PMID: 39713874 PMC: 11848162. DOI: 10.1002/alz.14443.

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