» Articles » PMID: 39713519

Analysis of Blood Sodium Level in Autism Spectrum Disorder

Overview
Date 2024 Dec 23
PMID 39713519
Authors
Affiliations
Soon will be listed here.
Abstract

Introduction: A number of recent studies have brought attention to the involvement of dietary salt and blood sodium levels in the etiopathogenesis of autism. In our study, by comparing the blood sodium levels of children with autism spectrum disease (ASD) and healthy children, we aimed to shed light on the etiopathogenesis of ASD.

Method: We retrospectively analyzed the blood sodium levels obtained from the 4-year follow-up of 84 children (42 with ASD and 42 controls).

Results: According to the comparison of blood sodium levels obtained from the 4-year follow-up of children in the ASD and control groups, no significant difference was found between the blood sodium levels of both groups.

Discussion: The notion that blood sodium levels influence the progression of autism is novel, and the majority of material on this topic comes from animal trials. The results of the few human-focused studies are controversial. More studies are needed to elucidate the role of blood sodium levels and salt consumption in the etiology of autism.

References
1.
Good P . Do salt cravings in children with autistic disorders reveal low blood sodium depleting brain taurine and glutamine?. Med Hypotheses. 2011; 77(6):1015-21. DOI: 10.1016/j.mehy.2011.08.038. View

2.
Cordoba J, Gottstein J, Blei A . Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis. J Hepatol. 1998; 29(4):589-94. DOI: 10.1016/s0168-8278(98)80154-2. View

3.
Chidambaram S, Tuladhar S, Bhat A, Mahalakshmi A, Ray B, Essa M . Autism and Gut-Brain Axis: Role of Probiotics. Adv Neurobiol. 2020; 24:587-600. DOI: 10.1007/978-3-030-30402-7_21. View

4.
Momeni N, Nordstrom B, Horstmann V, Avarseji H, Sivberg B . Alterations of prolyl endopeptidase activity in the plasma of children with autistic spectrum disorders. BMC Psychiatry. 2005; 5:27. PMC: 1190193. DOI: 10.1186/1471-244X-5-27. View

5.
Moritz M, Ayus J . New aspects in the pathogenesis, prevention, and treatment of hyponatremic encephalopathy in children. Pediatr Nephrol. 2009; 25(7):1225-38. PMC: 2874061. DOI: 10.1007/s00467-009-1323-6. View