Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Cardiovascular Diseases

Overview

Journal J Inflamm Res

Publisher Dove Medical Press

Date 2022 Jun 1

PMID 35642214

Authors

Menglong Wang

Wei Pan

Yao Xu

Jishou Zhang

Jun Wan

Hong Jiang

Affiliations

Soon will be listed here.

Abstract

Microglia are tissue-resident macrophages of the central nervous system (CNS). In the CNS, microglia play an important role in the monitoring and intervention of synaptic and neuron-level activities. Interventions targeting microglia have been shown to improve the prognosis of various neurological diseases. Recently, studies have observed the activation of microglia in different cardiovascular diseases. In addition, different approaches that regulate the activity of microglia have been shown to modulate the incidence and progression of cardiovascular diseases. The change in autonomic nervous system activity after neuroinflammation may be a potential intermediate link between microglia and cardiovascular diseases. Here, in this review, we will discuss recent updates on the regulatory role of microglia in hypertension, myocardial infarction and ischemia/reperfusion injury. We propose that microglia serve as neuroimmune modulators and potential targets for cardiovascular diseases.

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