Reproductive Factors and Risk of Epithelial Ovarian Cancer: Results from the Asia Cohort Consortium

Overview

Journal Br J Cancer

Specialty Oncology

Date 2024 Dec 20

PMID 39706987

Authors

Melissa A Merritt

Sarah Krull Abe

Md Rashedul Islam

Md Shafiur Rahman

Eiko Saito

Ryoko Katagiri

Aesun Shin

Ji-Yeob Choi

Loic Le Marchand

Jeffrey L Killeen

Yu-Tang Gao

Akiko Tamakoshi

Woon-Puay Koh

Ritsu Sakata

Norie Sawada

Ichiro Tsuji

Yumi Sugawara

Jeongseon Kim

Sue K Park

Sun-Seog Kweon

Xiao-Ou Shu

Takashi Kimura

Jian-Min Yuan

Shoichiro Tsugane

Seiki Kanemura

Yukai Lu

Min-Ho Shin

Wanqing Wen

Habibul Ahsan

Paolo Boffetta

Kee Seng Chia

Keitaro Matsuo

You-Lin Qiao

Nathaniel Rothman

Wei Zheng

Manami Inoue

Daehee Kang

Affiliations

Soon will be listed here.

Abstract

Background: There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.

Methods: This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium. A Cox proportional hazards regression model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for age, parity and cohort.

Results: After a mean = 17.0 years (SD = 6.3) of follow-up, 674 incident invasive EOC cases were identified among 325,626 women. In multivariable adjusted models we observed an inverse association with parity (5+ children vs. 0, HR = 0.44, 95% CI = 0.28-0.68, Ptrend < 0.001), and a positive association with increasing menopausal age (55+ years vs. <45, HR = 1.77, 95% CI = 1.05-3.01, Ptrend = 0.02) for risk of all EOC.

Conclusions: In this large study of Asian women we identified an inverse association with parity and a positive association with higher menopausal age in relation to EOC risk. Further work is needed to understand EOC risk factors for rare histologic subtypes that occur more frequently in Asian populations.

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