Feasibility of Relaxation Along a Fictitious Field in the 2nd Rotating Frame (T) Mapping in the Human Myocardium at 3 T

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2024 Dec 19

PMID 39697300

Authors

Joao Tourais

Masa Bozic-Iven

Yidong Zhao

Qian Tao

Iain Pierce

Christian Nitsche

George D Thornton

Lothar R Schad

Thomas A Treibel

Sebastian Weingartner

Mehmet Akcakaya

Affiliations

Soon will be listed here.

Abstract

Purpose: Evaluate the feasibility of quantification of Relaxation Along a Fictitious Field in the 2nd rotating frame (RAFF2) relaxation times in the human myocardium at 3 T.

Methods: mapping was performed using a breath-held ECG-gated acquisition of five images: one without preparation, three preceded by RAFF2 trains of varying duration, and one preceded by a saturation prepulse. Pixel-wise maps were obtained after three-parameter exponential fitting. The repeatability of , , and was assessed in phantom via the coefficient of variation (CV) across three repetitions. In seven healthy subjects, was tested for precision, reproducibility, inter-subject variability, and image quality (IQ) on a Likert scale (1 = Nondiagnostic, 5 = Excellent). Additionally, mapping was performed in three patients with suspected cardiovascular disease, comparing it to late gadolinium enhancement (LGE), native , , and ECV mapping.

Results: In phantom, showed good repeatability (CV < 1.5%) while showing no ( ) and high ( ) correlation with and , respectively. Myocardial maps exhibited overall acceptable image quality (IQ = 3.0 1.0) with moderate artifact levels, stemming from off-resonances near the coronary sinus. Average time across subjects and repetitions was 79.1 7.3 ms. Good precision (7.6 1.4%), reproducibility (1.0 0.6%), and low inter-subject variability (10.0 1.8%) were obtained. In patients, visual agreement of the infarcted area was observed in the map and LGE.

Conclusion: Myocardial quantification at 3 T was successfully achieved in a single breath-hold with acceptable image quality, albeit with residual off-resonance artifacts. Nonetheless, preliminary clinical data indicate potential sensitivity of mapping to myocardial infarction detection without the need for contrast agents, but off-resonance artifacts mitigation warrants further investigation.

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