MRI Contrast from Relaxation Along a Fictitious Field (RAFF)

Overview

Journal Magn Reson Med

Publisher Wiley

Specialty Radiology

Date 2010 Aug 27

PMID 20740665

Citations 45

Authors

Timo Liimatainen

Dennis J Sorce

Robert OConnell

Michael Garwood

Shalom Michaeli

Affiliations

Soon will be listed here.

Abstract

A new method to measure rotating frame relaxation and to create contrast for MRI is introduced. The technique exploits relaxation along a fictitious field (RAFF) generated by amplitude- and frequency-modulated irradiation in a subadiabatic condition. Here, RAFF is demonstrated using a radiofrequency pulse based on sine and cosine amplitude and frequency modulations of equal amplitudes, which gives rise to a stationary fictitious magnetic field in a doubly rotating frame. According to dipolar relaxation theory, the RAFF relaxation time constant (T(RAFF)) was found to differ from laboratory frame relaxation times (T(1) and T(2)) and rotating frame relaxation times (T(1ρ) and T(2ρ)). This prediction was supported by experimental results obtained from human brain in vivo and three different solutions. Results from relaxation mapping in human brain demonstrated the ability to create MRI contrast based on RAFF. The value of T(RAFF) was found to be insensitive to the initial orientation of the magnetization vector. In the RAFF method, the useful bandwidth did not decrease as the train length increased. Finally, as compared with an adiabatic pulse train of equal duration, RAFF required less radiofrequency power and therefore can be more readily used for rotating frame relaxation studies in humans.

Citing Articles

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Feasibility of relaxation along a fictitious field in the 2nd rotating frame (T) mapping in the human myocardium at 3 T.

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References

Bendall M, Garwood M, Ugurbil K, Pegg D . Adiabatic refocusing pulse which compensates for variable rf power and off-resonance effects. Magn Reson Med. 1987; 4(5):493-9. DOI: 10.1002/mrm.1910040510. View

Michaeli S, Sorce D, Idiyatullin D, Ugurbil K, Garwood M . Transverse relaxation in the rotating frame induced by chemical exchange. J Magn Reson. 2004; 169(2):293-9. DOI: 10.1016/j.jmr.2004.05.010. View

Michaeli S, Grohn H, Grohn O, Sorce D, Kauppinen R, Springer Jr C . Exchange-influenced T2rho contrast in human brain images measured with adiabatic radio frequency pulses. Magn Reson Med. 2005; 53(4):823-9. DOI: 10.1002/mrm.20428. View

Rooney W, Johnson G, Li X, Cohen E, Kim S, Ugurbil K . Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. Magn Reson Med. 2007; 57(2):308-18. DOI: 10.1002/mrm.21122. View

Kettunen M, Sierra A, Narvainen M, Valonen P, Yla-Herttuala S, Kauppinen R . Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma. Radiology. 2007; 243(3):796-803. DOI: 10.1148/radiol.2433052077. View

Vaughan J, Garwood M, Collins C, Liu W, Delabarre L, Adriany G . 7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images. Magn Reson Med. 2001; 46(1):24-30. DOI: 10.1002/mrm.1156. View

Hakumaki J, Grohn O, Tyynela K, Valonen P, Yla-Herttuala S, Kauppinen R . Early gene therapy-induced apoptotic response in BT4C gliomas by magnetic resonance relaxation contrast T1 in the rotating frame. Cancer Gene Ther. 2002; 9(4):338-45. DOI: 10.1038/sj.cgt.7700450. View

Michaeli S, Oz G, Sorce D, Garwood M, Ugurbil K, Majestic S . Assessment of brain iron and neuronal integrity in patients with Parkinson's disease using novel MRI contrasts. Mov Disord. 2006; 22(3):334-40. DOI: 10.1002/mds.21227. View

Palmer 3rd A, Kroenke C, Loria J . Nuclear magnetic resonance methods for quantifying microsecond-to-millisecond motions in biological macromolecules. Methods Enzymol. 2001; 339:204-38. DOI: 10.1016/s0076-6879(01)39315-1. View

10.

Michaeli S, Sorce D, Springer Jr C, Ugurbil K, Garwood M . T1rho MRI contrast in the human brain: modulation of the longitudinal rotating frame relaxation shutter-speed during an adiabatic RF pulse. J Magn Reson. 2006; 181(1):135-47. DOI: 10.1016/j.jmr.2006.04.002. View

11.

Hsu J, Glover G . Rapid MRI method for mapping the longitudinal relaxation time. J Magn Reson. 2006; 181(1):98-106. DOI: 10.1016/j.jmr.2006.03.014. View

12.

Witschey 2nd W, Borthakur A, Elliott M, Mellon E, Niyogi S, Wallman D . Artifacts in T1 rho-weighted imaging: compensation for B(1) and B(0) field imperfections. J Magn Reson. 2007; 186(1):75-85. PMC: 1995435. DOI: 10.1016/j.jmr.2007.01.015. View

13.

Haase A . Snapshot FLASH MRI. Applications to T1, T2, and chemical-shift imaging. Magn Reson Med. 1990; 13(1):77-89. DOI: 10.1002/mrm.1910130109. View

14.

Vaughan J, Adriany G, Garwood M, Yacoub E, Duong T, Delabarre L . Detunable transverse electromagnetic (TEM) volume coil for high-field NMR. Magn Reson Med. 2002; 47(5):990-1000. DOI: 10.1002/mrm.10141. View

15.

Borthakur A, Mellon E, Niyogi S, Witschey W, Kneeland J, Reddy R . Sodium and T1rho MRI for molecular and diagnostic imaging of articular cartilage. NMR Biomed. 2006; 19(7):781-821. PMC: 2896046. DOI: 10.1002/nbm.1102. View

16.

Witschey W, Borthakur A, Elliott M, Mellon E, Niyogi S, Wang C . Compensation for spin-lock artifacts using an off-resonance rotary echo in T1rhooff-weighted imaging. Magn Reson Med. 2006; 57(1):2-7. PMC: 2877388. DOI: 10.1002/mrm.21134. View

17.

SILVER M, Joseph R, Chen C, Sank V, Hoult D . Selective population inversion in NMR. Nature. 1984; 310(5979):681-3. DOI: 10.1038/310681a0. View

18.

Grohn OHJ , Kettunen M, Makela H, Penttonen M, Pitkanen A, Lukkarinen J . Early detection of irreversible cerebral ischemia in the rat using dispersion of the magnetic resonance imaging relaxation time, T1rho. J Cereb Blood Flow Metab. 2000; 20(10):1457-66. DOI: 10.1097/00004647-200010000-00007. View

19.

Deschamps M, Kervern G, Massiot D, Pintacuda G, Emsley L, Grandinetti P . Superadiabaticity in magnetic resonance. J Chem Phys. 2008; 129(20):204110. DOI: 10.1063/1.3012356. View

20.

Grohn H, Michaeli S, Garwood M, Kauppinen R, Grohn O . Quantitative T(1rho) and adiabatic Carr-Purcell T2 magnetic resonance imaging of human occipital lobe at 4 T. Magn Reson Med. 2005; 54(1):14-9. DOI: 10.1002/mrm.20536. View