Skeletal Stem Cells: A Basis for Orthopaedic Pathology and Tissue Repair

Overview

Journal J Bone Joint Surg Am

Specialties General Surgery
Orthopedics

Date 2024 Dec 18

PMID 39693451

Authors

Ting Cong

Kyle W Morse

Branden R Sosa

Joseph M Lane

Scott A Rodeo

Matthew B Greenblatt

Affiliations

Soon will be listed here.

Abstract

➢ Skeletal stem cells (SSCs) continually replenish mature cell populations to support skeletal homeostasis.➢ SSCs repopulate by self-renewal, have multilineage potential, and are long-lived in vivo.➢ SSCs express specific combinations of cell surface markers that reflect their lineage identity.➢ SSCs adapt to their anatomic environment to support regional differences in skeletal behavior and pathology.

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